R 59-022
R 59-022 structure
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Common Name | R 59-022 | ||
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| CAS Number | 93076-89-2 | Molecular Weight | 459.57800 | |
| Density | 1.26g/cm3 | Boiling Point | 619.8ºC at 760mmHg | |
| Molecular Formula | C27H26FN3OS | Melting Point | N/A | |
| MSDS | USA | Flash Point | 328.6ºC | |
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Diacylglycerol kinase epsilon in bovine and rat photoreceptor cells. Light-dependent distribution in photoreceptor cells.
Exp. Eye Res. 112 , 139-50, (2013) The present study shows the selective light-dependent distribution of 1,2-diacylglycerol kinase epsilon (DAGKɛ) in photoreceptor cells from bovine and albino rat retina. Immunofluorescence microscopy in isolated rod outer segments from bleached bovine retinas... |
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Insulin action on polyunsaturated phosphatidic acid formation in rat brain: an "in vitro" model with synaptic endings from cerebral cortex and hippocampus.
Neurochem. Res. 34(7) , 1236-48, (2009) The highly efficient formation of phosphatidic acid from exogenous 1-stearoyl-2-arachidonoyl-sn-glycerol (SAG) in rat brain synaptic nerve endings (synaptosomes) from cerebral cortex and hippocampus is reported. Phosphatidic acid synthesized from SAG or 1,2-d... |
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The role of diacylglycerol as a modulator of oxytocin-stimulated phasic contractions in myometrium from pregnant and nonpregnant rats.
Am. J. Obstet. Gynecol. 182(4) , 943-9, (2000) The role of diacylglycerol in the phosphatidylinositol-signaling pathway is to activate protein kinase C. In the myometrium, protein kinase C activation leads to inhibition of phasic contractions. These studies are designed to determine why stimulation of the... |
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Differentiation of HL-60 cells to granulocytes involves regulation of select diacylglycerol kinases (DGKs).
J. Cell. Biochem. 94(4) , 774-93, (2005) Diacylglycerol Kinases (DGKs) are a family of enzymes that regulate the levels of different pools of diacylglycerol (DAG), affecting DAG-mediated signal transduction. Since DAG is known to play several important regulatory roles in granulocyte physiology, we ... |
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Phospholipase C signaling involvement in macrotubule assembly and activation of the mechanism regulating protoplast volume in plasmolyzed root cells of Triticum turgidum.
New Phytol. 178(2) , 267-82, (2008) The role of phosphoinositide-specific phospholipase C (PI-PLC) signaling in the macrotubule-dependent protoplast volume regulation in plasmolyzed root cells of Triticum turgidum was investigated. At the onset of hyperosmotic stress, PI-PLC activation was docu... |
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A dual role for diacylglycerol kinase generated phosphatidic acid in autoantibody-induced neutrophil exocytosis.
Mol. Med. 17(11-12) , 1242-52, (2011) Dysregulated release of neutrophil azurophilic granules causes increased tissue damage and amplified inflammation during autoimmune disease. Antineutrophil cytoplasmic antibodies (ANCAs) are implicated in the pathogenesis of small vessel vasculitis and promot... |
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Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Anticancer Drugs 13(7) , 725-33, (2002) Modulation of protein kinase C (PKC) activity has been demonstrated to either prevent or enhance drug-induced apoptosis in various tissue types. We tested four novel modulators of PKC activity in comparison to the phorbol ester 12-O-tetradecanoylphorbol-13-ac... |
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Diacylglycerol mediates the T-cell receptor-driven Ca(2+) influx in T cells by a novel mechanism independent of protein kinase C activation.
J. Cell. Biochem. 78(2) , 222-30, (2000) The mechanism of Ca(2+) influx in nonexcitable cells is not known yet. According to the capacitative hypothesis, Ca(2+) influx is triggered by IP(3)-mediated Ca(2+) release from the intracellular Ca(2+) stores. Conversely, many workers have reported a lack of... |
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Diacylglycerol kinase alpha regulates globular adiponectin-induced reactive oxygen species.
Free Radic. Res. 45(3) , 336-41, (2011) It has previously been reported that the globular form of adiponectin (gAd), mature adipocyte-derived cytokine, induced generation of reactive oxygen species (ROS) and nitric oxide (NO) in the murine macrophage cell line RAW 264. This study investigated wheth... |
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Streptococcus mutans diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy.
J. Med. Microbiol. 60(Pt 5) , 625-30, (2011) Aciduricity is a major cariogenic characteristic of Streptococcus mutans, and various genes have been implicated in this ability of S. mutans. Sixteen S. mutans mutant strains, each defective in a different gene, were constructed and their aciduricity was ass... |