RG14620
RG14620 structure
|
Common Name | RG14620 | ||
|---|---|---|---|---|
| CAS Number | 136831-49-7 | Molecular Weight | 275.133 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 418.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C14H8Cl2N2 | Melting Point | 155 °C | |
| MSDS | Chinese USA | Flash Point | 206.7±28.7 °C | |
|
Photoinstability of some tyrphostin drugs: chemical consequences of crystallinity.
Pharm. Res. 12(11) , 1708-15, (1995) The purpose of this work was to study the photostability of the antiproliferative tyrphostin drug compounds RG 13022(I) and RG 14620(II) as a part of preformulation program.The compounds were exposed to cool white fluorescent light in solution as well as in t... |
|
|
Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
J. Cell Physiol. 211(3) , 803-15, (2007) Inhibiting epidermal growth factor-receptor (ErbB-1) represents a powerful anticancer strategy. Activation of retinoid pathways is also in development for cancer treatment. Retinoic acid receptor-beta-the tumor suppressor and main retinoid mediator--is silenc... |
|
|
[Effect of signal transduction inhibitors on human endometrial carcinoma cells with differential PTEN gene expression].
Zhonghua Fu Chan Ke Za Zhi 44(9) , 681-5, (2009) To investigate the apoptotic and proliferation effects of signal transduction inhibitors on human endometrial carcinoma cells with different PTEN gene expression.PTEN antisense oligonucleotide and pcDNA3.1/PTEN vector contained PTEN gene were transfected into... |
|
|
Antiproliferative effects of tyrosine kinase inhibitors (tyrphostins) on human bladder and renal carcinoma cells.
J. Surg. Res. 59(6) , 675-80, (1995) Growth factor receptors with tyrosine kinase activity mediate paracrine and autocrine growth regulation of normal and malignant cells. The epidermal growth factor receptor (EGF-R) is a tyrosine kinase transmembrane protein that is overexpressed by many epithe... |
|
|
Tyrphostins and retinoids cooperate during inhibition of in vitro growth of ovarian cancer cells.
Cancer Lett. 189(2) , 147-56, (2003) Chemoresistance of ovarian cancer can be overcome by co-administration of retinoids, albeit clinical proof of this hypothesis is pending. Moreover, growth factor/c-erbB signaling is crucial for ovarian tumor growth/chemosensitivity. Retinoids and c-erbB modul... |
|
|
Dispositional characteristics of a tyrosine kinase inhibitor (RG 14620) in rats and rabbits following intravenous administration or dermal application.
Drug Metab. Dispos. 22(2) , 216-23, (1994) Based on its epidermal growth factor receptor-mediated tyrosine kinase inhibitory activity, (Z)-alpha-[(3,5-dichlorophenyl)methylene]-3- pyridylacetonitrile (RG 14620) is undergoing evaluation as a topical drug for psoriasis. Disposition studies were conducte... |
|
|
EGFR- and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial cancer cells.
Mol. Cell Biochem. 361(1-2) , 19-29, (2012) Loss or mutation of the PTEN (phosphatase and tensin homologue deleted on chromosome 10) gene is associated with resistance to epidermal growth factor receptor (EGFR) inhibitors. However, the mechanism underlying remains elusive. In this study, we aimed to ex... |