IAA-94
IAA-94 structure
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Common Name | IAA-94 | ||
|---|---|---|---|---|
| CAS Number | 54197-31-8 | Molecular Weight | 357.22800 | |
| Density | 1.401g/cm3 | Boiling Point | 537.2ºC at 760 mmHg | |
| Molecular Formula | C17H18Cl2O4 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 278.7ºC | |
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Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current.
Oncotarget 5(22) , 11252-68, (2014) Epidemiological and preclinical studies propose that metformin, a first-line drug for type-2 diabetes, exerts direct antitumor activity. Although several clinical trials are ongoing, the molecular mechanisms of this effect are unknown. Here we show that chlor... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Toxicity and disruption of midgut physiology in larvae of the European corn borer, Ostrinia nubilalis, by anion transporter blockers.
Arch. Insect Biochem. Physiol. 70(3) , 151-61, (2009) In this study, four blockers of anion transporters (ATs) belonging to four different classes of organic acids, including DIDS (4, 4'-diisothiocyanatostilbene-2, 2'- disulfonic acid; a stilbene disulfonic acid), NPPB [(5-nitro-2-(3-phenylpropylamino) benzoic a... |
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Intracellular signalling pathways in the vasoconstrictor response of mouse afferent arterioles to adenosine.
Acta Physiol. (Oxf.) 191(2) , 89-97, (2007) Adenosine causes vasoconstriction of afferent arterioles of the mouse kidney through activation of adenosine A(1) receptors and Gi-mediated stimulation of phospholipase C. In the present study, we further explored the signalling pathways by which adenosine ca... |
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The glutamate aspartate transporter (GLAST) mediates L-glutamate-stimulated ascorbate-release via swelling-activated anion channels in cultured neonatal rodent astrocytes.
Cell Biochem. Biophys. 65(2) , 107-19, (2013) Vitamin C (ascorbate) plays important neuroprotective and neuromodulatory roles in the mammalian brain. Astrocytes are crucially involved in brain ascorbate homeostasis and may assist in regenerating extracellular ascorbate from its oxidised forms. Ascorbate ... |
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Effects of chloride channel blockers on rat renal vascular responses to angiotensin II and norepinephrine.
Am. J. Physiol. Renal Physiol. 286(2) , F323-30, (2004) The aim of the present study was to investigate the role of Ca2+-activated Cl- channels in the renal vasoconstriction elicited by angiotensin II (ANG II) and norepinephrine (NE). Renal blood flow (RBF) was measured in vivo using electromagnetic flowmetry. Rat... |
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Role of Cl- currents in rat aortic smooth muscle activation by prostaglandin F2 alpha.
Eur. J. Pharmacol. 481(2-3) , 133-40, (2003) The aim of this study was to determine the role of Cl(-) channel activation in prostaglandin F(2 alpha)-stimulated aortic contraction and in membrane depolarization during stimulation with prostaglandin F(2 alpha) in an aortic smooth muscle cell line (A7r5). ... |
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Roles of volume-sensitive chloride channel in excitotoxic neuronal injury.
J. Neurosci. 27(6) , 1445-55, (2007) Excitotoxicity is associated with stroke, brain trauma, and a number of neurodegenerative disorders. In the brain, during excitotoxic insults, neurons undergo rapid swelling in both the soma and dendrites. Focal swellings along the dendrites called varicositi... |
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Blockade of chloride intracellular ion channel 1 stimulates Abeta phagocytosis.
J. Neurosci. Res. 86(11) , 2488-98, (2008) In amyloid-beta (Abeta)-stimulated microglial cells, blockade of chloride intracellular ion channel 1 (CLIC1) reverts the increase in tumor necrosis factor-alpha and nitric oxide (NO) production and results in neuroprotection of cocultured neurons. This effec... |
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The volume-sensitive chloride channel inhibitors prevent both contractile dysfunction and apoptosis induced by doxorubicin through PI3kinase, Akt and Erk 1/2.
Eur. J. Heart Fail. 10(1) , 39-46, (2008) Contractile dysfunction and cardiomyopathies secondary to apoptotic cell death are limiting factors for treating cancer with doxorubicin. Inhibition of volume-sensitive chloride currents (I(Cl,vol)) has been reported to blunt doxorubicin-induced apoptosis in ... |