Clorsulon
Clorsulon structure
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Common Name | Clorsulon | ||
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| CAS Number | 60200-06-8 | Molecular Weight | 380.656 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 651.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C8H8Cl3N3O4S2 | Melting Point | 194-203°C | |
| MSDS | Chinese USA | Flash Point | 348.0±34.3 °C | |
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Efficacy of an anthelmintic combination in sheep infected with Fasciola hepatica resistant to albendazole and clorsulon.
Exp. Parasitol. 136 , 59-62, (2014) In the current study, we identified five sheep flocks with fasciolosis in the province of León (northwestern Spain) in order to determine the anthelmintic resistance status to three commonly used anthelmintics, namely albendazole (ABZ), triclabendazole (TCBZ)... |
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Intraspecific mitochondrial DNA variation of Fasciola hepatica eggs from sheep with different level of anthelmintic resistance.
Parasitol. Res. 113(7) , 2733-41, (2014) In the current study, Fasciola hepatica strains of sheep with different degrees of resistance to anthelmintics were analyzed by sequencing the cytochrome C oxidase (COX1) and the NADH dehydrogenase (NAD1) subunits. The strains were as follows: LS, susceptible... |
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Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle.
Vet. Parasitol. 162(3-4) , 278-84, (2009) The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nitroxynil, clorsulon and ivermectin with oral and pour-on com... |
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Fasciolicides: efficacy, actions, resistance and its management.
Vet. J. 158(2) , 81-112, (1999) The modes of action of fasciolicides are described. Closantel and other salicylanilides interfere with energy metabolism by uncoupling oxidative phosphorylation in the fluke. Other fasciolicides are believed to have a metabolic action-halogenated phenols (via... |
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Activity of oxyclozanide, nitroxynil, clorsulon and albendazole against adult triclabendazole-resistant Fasciola hepatica.
Vet. Rec. 148(23) , 723-4, (2001)
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Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR mice [corrected and reapublished in J Helminthol 1996 Mar;70(1):95-6].
J. Helminthol. 69(4) , 373-4, (1995) Female ICR mice, 5 to 6 weeks old, were exposed by stomach tube to 25 metacercarial cysts of Echinostoma caproni per mouse. At 14 days post-exposure, mice were fed by stomach tube clorsulon (1000 mg/kg, 500 mg/kg and 100 mg/kg) or rafoxanide (50 mg/kg, 25 mg/... |
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Effects of the anthelmintics clorsulon, rafoxanide, mebendazole and arprinocid on Echinostoma caproni in ICR mice.
J. Helminthol. 70(1) , 95-6, (1996) Female ICR mice, 5 to 6 weeks old, were exposed by stomach tube to 25 metacercarial cysts of Echinostoma caproni per mouse. At 14 days post-exposure, mice were fed by stomach tube clorsulon (1000 mg/kg, 500 mg/kg and 100 mg/ kg) or rafoxanide (50 mg/kg, 25 mg... |
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Field trial on comparative efficacy of four fasciolicides against natural liver fluke infection in cattle.
Vet. Parasitol. 135(3-4) , 279-85, (2006) A controlled trial was conducted to evaluate the current efficacy of albendazole (ABZ), rafoxanide (RFX), triclabendazole (TRC) or clorsulon (CLS) against Fasciola hepatica in naturally infected cattle. This trial was conducted in Turkey during the spring, th... |
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Ultrastructural observations on oral ingestion and trans-tegumental uptake of clorsulon by the liver fluke, Fasciola hepatica.
Parasitol. Res. 95(3) , 201-12, (2005) Three experiments have been carried out in vitro to determine the effect of oral and trans-tegumental uptake of clorsulon on the fine structure of the tegument and gut of Fasciola hepatica. Changes were assessed by transmission electron microscopy. In the fir... |
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Clorsulon pharmacokinetics in sheep and goats following oral and intravenous administration.
J. Vet. Pharmacol. Ther. 15(3) , 282-91, (1992) Clorsulon was measured in plasma and urine of sheep and goats after administration of a single intravenous (i.v.) and after a single oral dose of 7 mg/kg. A three-compartment model with elimination occurring from the central compartment was determined to best... |