Polyvinylpyrrolidone
Polyvinylpyrrolidone structure
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Common Name | Polyvinylpyrrolidone | ||
|---|---|---|---|---|
| CAS Number | 9003-39-8 | Molecular Weight | 111.1418 (monomer) | |
| Density | 1.144g/cm3 | Boiling Point | 217.6ºC at 760 mmHg | |
| Molecular Formula | (C6H9NO)n | Melting Point | 130ºC | |
| MSDS | Chinese USA | Flash Point | 93.9ºC | |
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Solution growth of spherulitic rod and platelet calcium phosphate assemblies through polymer-assisted mesoscopic transformations.
Mater. Sci. Eng. C. Mater. Biol. Appl. 33(4) , 2175-91, (2013) Solution growth of apatite its precursors in the presence of urea commercial gelatin is found to lead, under appropriate conditions, to a rich spectrum of morphologies, among them high aspect ratio needles in uniform sturdy spherulitic assemblies resulting fr... |
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Curcumin amorphous solid dispersions: the influence of intra and intermolecular bonding on physical stability.
Pharm. Dev. Technol. 19(8) , 976-86, (2014) We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular interactions in delaying crystallization. Curcumin is an interesting model compound as it forms both intra and intermolecular hydroge... |
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Formulation and evaluation of clozapine orally disintegrating tablets prepared by direct compression.
Pharmazie 68(2) , 110-6, (2013) Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC) formation in the embryo will guide efforts to produce and expand HSPCs ex vivo. Here we show that sterile tonic inflammatory signaling regulates embryonic HSPC formatio... |
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NIR imaging spectroscopy for quantification of constituents in polymers thin films loaded with paracetamol.
Anal. Chim. Acta 765 , 37-44, (2013) Thin films loaded with the drug paracetamol were produced from polymer blends formed by hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG), at various mass ratios of polymers and drug defined by a D-optimal experiment... |
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Fast disintegrating tablets of nisoldipine for intra-oral administration.
Pharm. Dev. Technol. 19(6) , 641-50, (2014) Nisoldipine is a calcium channel blocker with low and variable oral bioavailability. This was attributed to slow dissolution and presystemic metabolism. Accordingly, the objective of this work was to enhance the dissolution rate of nisoldipine to formulate fa... |
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Powder flow in an automated uniaxial tester and an annular shear cell: a study of pharmaceutical excipients and analytical data comparison.
Drug Dev. Ind. Pharm. 39(9) , 1476-83, (2013) An automated version of uniaxial powder flow testing has recently been developed and there is a need for experimental data from pharmaceutical powders.To compare the novel testing method with an annular shear cell using different pharmaceutical excipients. A ... |
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Effect of drug-polymer interactions on the aqueous solubility of milled solid dispersions.
Int. J. Pharm. 446(1-2) , 100-5, (2013) The role of molecular interactions in ball milled solid dispersions in determining the aqueous solubility of the poorly water-soluble drug, griseofulvin (GF) has been examined. Ball milled solid dispersions of GF and hydroxypropylmethylcellulose acetate succi... |
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Dissolution testing of amorphous solid dispersions.
Int. J. Pharm. 444(1-2) , 40-6, (2013) The main purpose of this study was to investigate the effect of different polymers, with varying physicochemical properties and molecular weight on the stability and dissolution of co-milled amorphous solid dispersions (ASDs) of piroxicam (PRX). The stability... |
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Solid dispersions of the penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA): formulation design and optimization studies.
Pharm. Dev. Technol. 19(7) , 806-12, (2014) The penta-ethyl ester prodrug of diethylenetriaminepentaacetic acid (DTPA), which exists as an oily liquid, was incorporated into a solid dispersion for oral administration by the solvent evaporation method using blends of polyvinylpyrrolidone (PVP), Eudragit... |
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Stabilization of HAC1 influenza vaccine by spray drying: formulation development and process scale-up.
Pharm. Res. 31(11) , 3006-18, (2014) Stable vaccines with long shelf lives and reduced dependency on the cold chain are ideal for stockpiling and rapid deployment during public emergencies, including pandemics. Spray drying is a low-cost process that has potential to produce vaccines stable at a... |