coenzyme Q10
coenzyme Q10 structure
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Common Name | coenzyme Q10 | ||
|---|---|---|---|---|
| CAS Number | 303-98-0 | Molecular Weight | 863.344 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 869.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C59H90O4 | Melting Point | 49-51 °C | |
| MSDS | Chinese USA | Flash Point | 324.6±34.3 °C | |
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Promotion of growth by Coenzyme Q10 is linked to gene expression in C. elegans
Biochem. Biophys. Res. Commun. 452(4) , 920-7, (2014) • We systematically examined the relation between Coenzyme Q (CoQ) and growth in C. elegans. • Novel molecular targets differentially expressed by endogenous (clk-1 mutants) or exogenous CoQ are provided. • The promotion of growth by CoQ in C. elegans is link... |
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A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
Nat. Cell Biol. 17 , 782-92, (2015) The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing. Mitochondria communicate with nuclei through retrograde signalling pathways t... |
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Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos.
J. Chromatogr. A. 1412 , 59-66, (2015) The analysis of lipid molecules in living organism is an important step in deciphering metabolic pathways. Recently, the zebrafish has been adopted as a valuable animal model system to perform in vivo metabolomics studies, however limited methodologies and pr... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Coumarins as new matrices for matrix-assisted laser-desorption/ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of hydrophobic compounds.
Anal. Chim. Acta 882 , 49-57, (2015) Hydrophobic compounds with hydroxyl, aldehyde or ketone groups are generally difficult to detect using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), because these compounds have low proton affinity and are poorly ionized by MALDI. ... |
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Effects of various squalene epoxides on coenzyme Q and cholesterol synthesis.
Biochim. Biophys. Acta 1841(7) , 977-86, (2014) 2,3-Oxidosqualene is an intermediate in cholesterol biosynthesis and 2,3:22,23-dioxidosqualene act as the substrate for an alternative pathway that produces 24(S),25-epoxycholesterol which effects cholesterol homeostasis. In light of our previous findings con... |
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Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.
J. Mol. Cell. Cardiol. 76 , 247-56, (2014) An increase of late Na(+) current (INaL) in cardiac myocytes can raise the cytosolic Na(+) concentration and is associated with activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and alterations of mitochondrial metabolism and Ca(2+) handlin... |
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Molecular, Physiological and Phenotypic Characterization of Paracoccus denitrificans ATCC 19367 Mutant Strain P-87 Producing Improved Coenzyme Q10.
Indian J. Microbiol. 55(2) , 184-93, (2015) Coenzyme Q10 (CoQ10) is a blockbuster nutraceutical molecule which is often used as an oral supplement in the supportive therapy for cardiovascular diseases, cancer and neurodegenerative diseases. It is commercially produced by fermentation process, hence con... |
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Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines.
PLoS ONE 10 , e0133656, (2015) The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration. Here, we performed cell-based screeni... |
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Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.
Antioxid. Redox Signal. 21(11) , 1571-81, (2014) Although uncoupling protein 2 (UCP2) negatively regulates intracellular reactive oxygen species (ROS) production and protects vascular function, its participation in vascular benefits of drugs used to treat cardiometabolic diseases is largely unknown. This st... |