TMRM Perchlorate
TMRM Perchlorate structure
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Common Name | TMRM Perchlorate | ||
|---|---|---|---|---|
| CAS Number | 115532-50-8 | Molecular Weight | 500.928 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H25ClN2O7 | Melting Point | 274–276℃ | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation.
Cell Death Dis. 6 , e1663, (2015) Mitochondrial fission and fusion are essential processes in the maintenance of the skeletal muscle function. The contribution of these processes to muscle development has not been properly investigated in vivo because of the early lethality of the models gene... |
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The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.
Arch. Toxicol. 88(9) , 1695-709, (2014) Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive ... |
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Selenium-containing chrysin and quercetin derivatives: attractive scaffolds for cancer therapy.
J. Med. Chem. 58 , 4250-65, (2015) Selenium-containing chrysin (SeChry) and 3,7,3',4'-tetramethylquercetin (SePQue) derivatives were synthesized by a microwave-based methodology. In addition to their improvement in terms of DPPH scavenging and potential GPx-like activities, when tested in a pa... |
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Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis.
Nat. Commun. 6 , 6201, (2015) The common pathological manifestation of cystic fibrosis (CF) is associated with an excessive lung inflammatory response characterized by interleukin-1β accumulation. CF airway epithelial cells show an exacerbated pro-inflammatory response to Pseudomonas aeru... |
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Heat Stress Induces Extended Plateau of Hsp70 Accumulation--A Possible Cytoprotection Mechanism in Hepatic Cells.
J. Cell. Biochem. 116 , 2365-74, (2015) The relevance of heat preconditioning resides in its ability to protect cells from different kinds of injury by induction of heat shock proteins, a process in which the intensity of heat stress (HS) and duration of subsequent recovery are vital. This study ev... |
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H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation.
Biochim. Biophys. Acta 1853(2) , 276-84, (2015) Dysfunction of cardiac energy metabolism plays a critical role in many cardiac diseases, including heart failure, myocardial infarction and ischemia-reperfusion injury and organ transplantation. The characteristics of these diseases can be elucidated in vivo,... |
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Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells.
Cell Death Differ. 22 , 1181-91, (2015) Tunneling nanotubes (TNTs) are F-actin-based membrane tubes that form between cells in culture and in tissues. They mediate intercellular communication ranging from electrical signalling to the transfer of organelles. Here, we studied the role of TNTs in the ... |
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Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.
Biochim. Biophys. Acta 1842(12 Pt A) , 2468-78, (2014) The cardiotoxicity induced by the anti-cancer doxorubicin involves increased oxidative stress, disruption of calcium homeostasis and activation of cardiomyocyte death. Nevertheless, antioxidants and caspase inhibitors often show little efficacy in preventing ... |
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Mitochondrial (dys)function - a factor underlying the variability of efavirenz-induced hepatotoxicity?
Br. J. Pharmacol. 172(7) , 1713-27, (2015) The non-nucleoside analogue reverse transcriptase inhibitor efavirenz is associated with hepatic toxicity and metabolic disturbances. Although the mechanisms involved are not clear, recent evidence has pinpointed a specific mitochondrial action of efavirenz a... |
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Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells.
FASEB J. 28(12) , 5122-35, (2014) Lon is a nuclear-encoded, mitochondrial protease that assists protein folding, degrades oxidized/damaged proteins, and participates in maintaining mtDNA levels. Here we show that Lon is up-regulated in several human cancers and that its silencing in RKO colon... |