Thymidine
Thymidine structure
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Common Name | Thymidine | ||
|---|---|---|---|---|
| CAS Number | 50-89-5 | Molecular Weight | 242.229 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 510.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C10H14N2O5 | Melting Point | 187-189ºC | |
| MSDS | Chinese USA | Flash Point | 262.3±32.9 °C | |
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DNase II-dependent DNA digestion is required for DNA sensing by TLR9.
Nat. Commun. 6 , 5853, (2015) DNase II digests DNA in endolysosomes. In the absence of DNase II, undigested DNA activates cytoplasmic DNA-sensing pathways. Little is known, however, about the role of DNase II in endolysosomal DNA sensing by TLR9. Here we show that DNase II is required for... |
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Oncogene-mediated regulation of p53 ISGylation and functions.
Oncotarget 5(14) , 5808-18, (2014) Oncogene-mediated cellular transformation is a multistep process involving activation of growth-promoting pathways as well as inactivation of tumor suppressors. We recently found that ISGylation of the p53 tumor suppressor is an important novel mechanism to c... |
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Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.
Nat. Commun. 6 , 6240, (2015) Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein f... |
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Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.
J. Cell Biol. 208(2) , 181-96, (2015) During mitosis, the spindle checkpoint senses kinetochores not properly attached to spindle microtubules and prevents precocious sister-chromatid separation and aneuploidy. The constitutive centromere-associated network (CCAN) at inner kinetochores anchors th... |
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Genotoxicity testing of esterified propoxylated glycerol (EPG).
Regul Toxicol Pharmacol 70 Suppl 2 , S131-42, (2014) Four versions of esterified propoxylated glycerols (EPGs) were evaluated for potential genotoxicity using a range of in vitro and in vivo assays. H-EPG-05 HR/SO 9:1, H-EPG-05 soyate, and H-EPG-14 soyate were non-mutagenic in reverse mutation assays (maximum c... |
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Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.
Blood 124(18) , 2767-74, (2014) Telomerase is a ribonucleoprotein enzyme that is necessary for overcoming telomere shortening in human germ and stem cells. Mutations in telomerase or other telomere-maintenance proteins can lead to diseases characterized by depletion of hematopoietic stem ce... |
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Vascular smooth muscle cell proliferation depends on caveolin-1-regulated polyamine uptake.
Biosci. Rep. 34(6) , e00153, (2014) Much evidence highlights the importance of polyamines for VSMC (vascular smooth muscle cell) proliferation and migration. Cav-1 (caveolin-1) was recently reported to regulate polyamine uptake in intestinal epithelial cells. The aim of the present study was to... |
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Wild-type and specific mutant androgen receptor mediates transcription via 17β-estradiol in sex hormone-sensitive cancer cells.
J. Cell Physiol. 230(7) , 1594-606, (2015) We previously encountered regulatory processes wherein dihydrotestosterone (DHT) exerted its inhibitory effect on parathyroid hormone-related protein (PTHrP) gene repression through the estrogen receptor (ER)α, but not the androgen receptor (AR), in breast ca... |
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Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20.
J. Cell Sci. 128(8) , 1639-53, (2015) Nek2 isoform A (Nek2A) is a presumed substrate of the anaphase-promoting complex/cyclosome containing Cdc20 (APC/C(Cdc20)). Nek2A, like cyclin A, is degraded in mitosis while the spindle checkpoint is active. Cyclin A prevents spindle checkpoint proteins from... |
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Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.
PLoS ONE 9(12) , e116048, (2014) Activating transcription factor 2 (ATF2) and its homolog ATF7 are phosphorylated at Thr-69/Thr-71 and at Thr-51/Thr-53, respectively, by stress-activated MAPKs regulating their transcriptional functions in G1 and S phases. However, little is known about the r... |