[Tyr1]-Somatostatin-14
![[Tyr1]-Somatostatin-14 Structure](https://image.chemsrc.com/caspic/177/59481-23-1.png)
[Tyr1]-Somatostatin-14 structure
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Common Name | [Tyr1]-Somatostatin-14 | ||
|---|---|---|---|---|
| CAS Number | 59481-23-1 | Molecular Weight | 1729.97000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C82H108N18O20S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.
J. Neuroendocrinol. 27 , 872-86, (2015) Ghrelin, a gut hormone originating from the post-translational cleavage of preproghrelin, is the endogenous ligand of growth hormone secretagogue receptor 1a (GHS-R1a). Within the growth hormone (GH) axis, the biological activity of ghrelin requires octanoyla... |
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Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.
Sci. Signal. 8 , ra113, (2015) Skeletal muscle is the largest organ, comprising 40% of the total body lean mass, and affects whole-body metabolism in multiple ways. We investigated the signaling pathways involved in this process using TSCmKO mice, which have a skeletal muscle-specific depl... |
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Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid.
EMBO J. 34 , 1875-88, (2015) MT1-MMP (MMP14) is a collagenolytic enzyme located at the cell surface and implicated in extracellular matrix (ECM) remodeling. Mmp14(-/-) mice present dwarfism, bone abnormalities, and premature death. We demonstrate herein that the loss of MT1-MMP also caus... |
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Combined treatment with GH and IGF-I: additive effect on cortical bone mass but not on linear bone growth in female rats.
Endocrinology 155(12) , 4798-807, (2014) The growth-promoting effect of combined therapy with GH and IGF-I in normal rats is not known. We therefore investigated the efficacy of treatment with recombinant human (rh)GH and/or rhIGF-I on longitudinal bone growth and bone mass in intact, prepubertal, f... |
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Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice.
Diabetologia 58(2) , 374-83, (2015) High intake of carbohydrates, particularly sucrose, in western societies is associated with the development of non-alcoholic fatty liver (NAFL) and diabetes mellitus. It is unclear whether this is related primarily to the carbohydrate quantity or to the hormo... |
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Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.
J. Cell Physiol. 230 , 2796-806, (2015) Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like-growth factor-1 (IGF-1) for endoch... |
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Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice.
Exp. Gerontol. 58 , 219-29, (2014) Disruption of the growth hormone (GH) axis promotes longevity and delays aging. In contrast, GH over-expression may lead to accelerated aging and shorter life. Calorie restriction (CR) improves insulin sensitivity and may extend lifespan. Long-lived Ames dwar... |
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The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.
PLoS ONE 9(10) , e109598, (2014) Two knockout mouse models for the autism candidate gene Neurobeachin (Nbea) have been generated independently. Although both models have similar phenotypes, one striking difference is the dwarf phenotype observed in the heterozygous configuration of the GH240... |
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Permanent uncoupling of male-specific CYP2C11 transcription/translation by perinatal glutamate.
Toxicol. Appl. Pharmacol. 284(1) , 79-91, (2015) Perinatal exposure of rats and mice to the typically reported 4mg/g bd wt dose of monosodium glutamate (MSG) results in a complete block in GH secretion as well as obesity, growth retardation and a profound suppression of several cytochrome P450s, including C... |
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The prolactin family hormones regulate vascular tone through NO and prostacyclin production in isolated rat aortic rings.
Acta Pharmacol. Sin. 36 , 572-86, (2015) Prolactin family hormones include growth hormone, placental lactogen and prolactin, which are able to regulate angiogenesis via NO and prostaglandins. However, their effects on vascular tone are not fully understood. The aim of this study was to evaluate the ... |