5-DIMETHYLAMINONAPHTHALENE-1-SULFONYL-GLYCINE
5-DIMETHYLAMINONAPHTHALENE-1-SULFONYL-GLYCINE structure
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Common Name | 5-DIMETHYLAMINONAPHTHALENE-1-SULFONYL-GLYCINE | ||
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| CAS Number | 1091-85-6 | Molecular Weight | 308.35300 | |
| Density | 1.381g/cm3 | Boiling Point | 525.7ºC at 760mmHg | |
| Molecular Formula | C14H16N2O4S | Melting Point | 159ºC | |
| MSDS | Chinese USA | Flash Point | 271.7ºC | |
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Phase separation kinetics in amorphous solid dispersions upon exposure to water.
Mol. Pharm. 12 , 1623-35, (2015) The purpose of this study was to develop a novel fluorescence technique employing environment-sensitive fluorescent probes to study phase separation kinetics in hydrated matrices of amorphous solid dispersions (ASDs) following storage at high humidity and dur... |
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Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies.
Bioorg. Med. Chem. 19 , 4202-4210, (2011) The specific binding of carrier ligands of antidiabetic vanadium(IV) and zinc(II) complexes into drug binding pockets of human serum albumin (HSA) has been investigated via displacement reactions of site markers such as warfarin and dansylglycine by different... |
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Immobilized fluorescent cyclodextrin on a cellulose membrane as a chemosensor for molecule detection.
Anal. Chem. 73 , 3126-3130, (2001) Dansylglycine-modified cyclodextrin (DnsC4-beta-CD) was prepared as a fluorescent host that is capable of being immobilized on a cellulose membrane (DnsC4-beta-CD membrane). DnsC4-beta-CD immobilized on the cellulose membrane decreased its fluorescence intens... |
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Epitope mapping and competitive binding of HSA drug site II ligands by NMR diffusion measurements.
J. Am. Chem. Soc. 126 , 14258-14266, (2004) It is important to characterize drug-albumin binding during drug discovery and lead optimization as strong binding may reduce bioavailability and/or increase the drug's in vivo half-life. Despite knowing about the location of human serum albumin (HSA) drug bi... |
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Monoacylglycerol binding to human serum albumin: evidence that monooleoylglycerol binds at the dansylsarcosine site.
J. Lipid Res. 39 , 1033-1038, (1998) The binding of monoacylglycerides of long-chain fatty acids to human serum albumin has been examined using monooleoylglycerol as the ligand. Binding was investigated using changes in tryptophan fluorescence and also the displacement of a variety of well-studi... |
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Sample enrichment in a single levitated droplet for capillary electrophoresis.
J. Chromatogr. B. Biomed. Sci. Appl. 714(1) , 39-46, (1998) This paper describes sample enrichment in a single levitated droplet for capillary electrophoresis (CE) analysis. The droplet was trapped in an acoustical field. The minute sample volumes needed for the enrichment procedure were precisely handled using a piez... |
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Endogenous ligand(s) decrease drug--protein binding in uremic sera: a fluorescence probe study.
Klin. Wochenschr. 61(13) , 649-53, (1983) Human serum albumin (HSA) was isolated and purified (greater than 97% purity) from normal sera, from sera of patients with severe chronic renal insufficiency and from sera to which a strongly protein bound acidic drug--clofibrinic acid--was added as a model l... |
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Binding sites of fluorescent probes on human serum albumin.
J. Pharm. Pharmacol. 46 , 300-304, (1994) Human serum albumin is known to have two major and selective drug binding sites, termed sites I and II. The fluorescent probes, dansylamide and dansylsarcosine selectively interact with sites I and II, respectively. However, the binding site of the fluorescen... |
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Albumin binding in uraemia: quantitative assessment of inhibition by endogenous ligands and carbamylation of albumin.
Eur. J. Clin. Pharmacol. 43(5) , 491-9, (1992) The binding capacity of human serum albumin (HSA) for small acidic molecules is known to be reduced in chronic renal failure (CRF). The contribution of competitive inhibition by accumulated endogenous ligands and of structural changes in HSA has now been eval... |
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Highly sensitive high-performance liquid chromatography-fluorimetric assay method for carboxypeptidase H activity.
J. Chromatogr. B, Biomed. Appl. 667(2) , 333-8, (1995) A rapid and sensitive high-performance liquid chromatographic (HPLC)-fluorimetric assay method has been developed for the determination of carboxypeptidase H activity based on the measurement of N-(5-dimethyl-aminonaphthalene-1-sulfonyl)glycine (dansyl-Gly) f... |