Bromobimane
Bromobimane structure
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Common Name | Bromobimane | ||
|---|---|---|---|---|
| CAS Number | 71418-44-5 | Molecular Weight | 271.11100 | |
| Density | 1.66g/cm3 | Boiling Point | 327.8ºC at 760 mmHg | |
| Molecular Formula | C10H11BrN2O2 | Melting Point | 152-154ºC | |
| MSDS | USA | Flash Point | 152.1ºC | |
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Dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation.
Environ. Toxicol. Pharmacol. 39(1) , 259-70, (2015) In the current study it was found that dieckol isolated from edible brown algae, Ecklonia cava (EC), as potent anti-proliferative and anti-angiogenic agent. Vascular endothelial growth factor (VEGF) induced EA.hy926 cell proliferation was suppressed by diecko... |
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Mg2+-dependent conformational changes and product release during DNA-catalyzed RNA ligation monitored by Bimane fluorescence.
Nucleic Acids Res. 43(1) , 40-50, (2015) Among the deoxyribozymes catalyzing the ligation of two RNA substrates, 7S11 generates a branched RNA containing a 2',5'-linkage. We have attached the small fluorogenic probe Bimane to the triphosphate terminated RNA substrate and utilized emission intensity ... |
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Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics.
J. Biol. Chem. 290 , 15785-98, (2015) G protein-coupled receptors (GPCRs) are remarkably versatile signaling systems that are activated by a large number of different agonists on the outside of the cell. However, the inside surface of the receptors that couple to G proteins has not yet been effec... |
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Sodium thiosulfate attenuates angiotensin II-induced hypertension, proteinuria and renal damage.
Nitric Oxide 42 , 87-98, (2014) Hypertension and proteinuria are important mediators of renal damage. Despite therapeutic interventions, the number of patients with end stage renal disease steadily increases. Hydrogen sulfide (H(2)S) is an endogenously produced gasotransmitter with vasodila... |
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Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death.
Oncogene 34 , 4032-43, (2015) Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discov... |
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Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity.
J. Food Sci. 80 , H2336-45, (2015) Fibrillation of alpha-synuclein (α-SN) is a critical process in the pathophysiology of several neurodegenerative diseases, especially Parkinson's disease. Application of bioactive inhibitory compounds from herbal extracts is a potential therapeutic approach f... |
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Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests.
Nanotoxicology 9 Suppl 1 , 13-24, (2015) Given the multiplicity of nanoparticles (NPs), there is a requirement to develop screening strategies to evaluate their toxicity. Within the EU-funded FP7 NanoTEST project, a panel of medically relevant NPs has been used to develop alternative testing strateg... |
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H2S induced coma and cardiogenic shock in the rat: Effects of phenothiazinium chromophores.
Clin. Toxicol. (Phila.) 53 , 525-39, (2015) Hydrogen sulfide (H2S) intoxication produces an acute depression in cardiac contractility-induced circulatory failure, which has been shown to be one of the major contributors to the lethality of H2S intoxication or to the neurological sequelae in surviving a... |
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Nelumbo nucifera leaves protect hydrogen peroxide-induced hepatic damage via antioxidant enzymes and HO-1/Nrf2 activation.
Food Funct. 6 , 1911-8, (2015) Naturally occurring phenolic compounds are widely found in plants. Here, the phenolic composition and hepatoprotective effect of the butanolic extract (BE) from Nelumbo nucifera leaves against H2O2-induced hepatic damage in cultured hepatocytes were investiga... |
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Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice.
Atherosclerosis 237(2) , 725-33, (2014) D-ribose-L-cysteine (ribose-cysteine) is a cysteine analogue designed to increase the synthesis of glutathione (GSH). GSH is a cofactor for glutathione peroxidase (GPx), the redox enzyme that catalyses the reduction of lipid peroxides. A low GPx activity and ... |