N,N-Dimethylglycine hydrochloride
N,N-Dimethylglycine hydrochloride structure
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Common Name | N,N-Dimethylglycine hydrochloride | ||
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| CAS Number | 2491-06-7 | Molecular Weight | 139.581 | |
| Density | 1.069g/cm3 | Boiling Point | 175.2ºC at 760 mmHg | |
| Molecular Formula | C4H10ClNO2 | Melting Point | 189-194 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 59.8ºC | |
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Exposure to the proton scavenger glycine under alkaline conditions induces Escherichia coli viability loss.
PLoS ONE 8(3) , e60328, (2013) Our previous work described a clear loss of Escherichia coli (E. coli) membrane integrity after incubation with glycine or its N-methylated derivatives N-methylglycine (sarcosine) and N,N-dimethylglycine (DMG), but not N,N,N-trimethylglycine (betaine), under ... |
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DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.
Am. J. Clin. Nutr. 97(6) , 1217-27, (2013) Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in... |
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Low folate status enhances pregnancy changes in plasma betaine and dimethylglycine concentrations and the association between betaine and homocysteine.
Am. J. Clin. Nutr. 97(6) , 1252-9, (2013) Folate, choline, and betaine participate in homocysteine metabolism. It is not known whether they interact during pregnancy.The objective was to investigate how folate status affects choline, betaine, and dimethylglycine during pregnancy.Fasting plasma folate... |
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Plasma choline and betaine correlate with serum folate, plasma S-adenosyl-methionine and S-adenosyl-homocysteine in healthy volunteers.
Clin. Chem. Lab Med. 51(3) , 683-92, (2013) Choline is essential for mammalian cell function. It plays a critical role in cell membrane integrity, neurotransmission, cell signaling and lipid metabolism. Moreover, choline is involved in methylation in two ways: a) its synthesis requires methyl groups do... |
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Metabolomics reveals the metabolic shifts following an intervention with rye bread in postmenopausal women--a randomized control trial.
Nutr. J. 11 , 88, (2012) Epidemiological studies have consistently shown that whole grain (WG) cereals can protect against the development of chronic diseases, but the underlying mechanism is not fully understood. Among WG products, WG rye is considered even more potent because of it... |
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Effects of N,N-dimethylglycine sodium salt on apparent digestibility, vitamin E absorption, and serum proteins in broiler chickens fed a high- or low-fat diet.
Poult. Sci. 92(5) , 1221-6, (2013) The objective of this study was to assess the effect of supplementation with sodium salt of N,N-dimethylglycine (DMG-Na) on apparent digestibility (AD) in broiler chickens fed low- and high-fat diets. Twenty-eight 1-d-old broiler chickens were fed one of the ... |
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Blood biomarkers of methylation in Down syndrome and metabolic simulations using a mathematical model.
Mol. Nutr. Food. Res. 56(10) , 1582-9, (2012) The study tests the metabolites of the methylation cycle in individuals with Down syndrome (DS) and applies a mathematical model in order to change this cycle by nutritional factors.We measured concentrations of the metabolites related to the methylation cycl... |
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Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study.
Br. J. Nutr. 110(2) , 330-6, (2013) Choline is an essential nutrient that is found in many food sources and plays a critical role in the development of the central nervous system. Animal studies have shown that choline status pre- and postnatally can have long-lasting effects on attention and m... |
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Treatment for mitochondrial disorders.
Cochrane Database Syst. Rev. 4 , CD004426, (2012) Mitochondrial respiratory chain disorders are the most prevalent group of inherited neurometabolic diseases. They present with central and peripheral neurological features usually in association with other organ involvement including the eye, the heart, the l... |
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A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma.
J. Lipid Res. 52(7) , 1435-45, (2011) Niemann-Pick type C1 (NPC1) disease is a rare, progressively fatal neurodegenerative disease for which there are no FDA-approved therapies. A major barrier to developing new therapies for this disorder has been the lack of a sensitive and noninvasive diagnost... |