Linsidomine hydrochloride
Linsidomine hydrochloride structure
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Common Name | Linsidomine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 16142-27-1 | Molecular Weight | 206.630 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H11ClN4O2 | Melting Point | 186 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase.
Cell Death Dis. 5 , e1410, (2014) Platelet activation is a frontline response to injury, not only essential for clot formation but also important for tissue repair. Indeed, the reparative influence of platelets has long been exploited therapeutically where application of platelet concentrates... |
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Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.
Exp. Neurol. 233(1) , 154-62, (2012) The role of taurine in regulating glucose-induced nitrosative stress has been examined in human Schwann cells, a model for understanding the pathogenesis of diabetic neuropathy. Exposure to high glucose increased nitrated proteins (1.56 fold p<0.05), inducibl... |
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Comparative kinetics of thiol oxidation in two distinct free-radical generating systems: SIN-1 versus AAPH.
Free Radic. Res. 46(10) , 1190-200, (2012) To study oxidative stress in biological systems, chemical compounds capable of producing free radicals have been widely used. Here, we compared two free-radical generators, 3-morpholinosydnonimine (SIN-1) and 2,2'-azo-bis(2-amidinopropane) hydrochloride (AAPH... |
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Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.
PLoS ONE 7(1) , e29789, (2012) In order to study oxidative stress in peripheral cells of Alzheimer's disease (AD) patients, immortalized lymphocytes derived from two peculiar cohorts of patients, referring to early onset AD (EOSAD) and subjects harboured AD related mutation (ADmut), were u... |
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Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.
J. Neurosci. 32(16) , 5573-84, (2012) Sodium-coupled, high-affinity choline transporters (CHTs) are inhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO⁻) donor]; ONOO⁻ can be produced from nitric oxide and reactive oxygen species during neurodegeneration. SIN-1 rapidly increases CHT... |
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Response of mitochondrial antioxidant system and respiratory pathways to reactive nitrogen species in pea leaves.
Physiol. Plant. 147(2) , 194-206, (2013) Nitric oxide (NO) has emerged as an important signaling molecule in plants, but little is known about the effects of reactive nitrogen species in plant mitochondria. In this study, the effects of DETA-NONOate, a pure NO slow generator, and of SIN-1 (3-morphol... |
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Topical combinations to treat microvascular dysfunction of chronic postischemia pain.
Anesth. Analg. 118(4) , 830-40, (2014) Growing evidence indicates that patients with complex regional pain syndrome (CRPS) exhibit tissue abnormalities caused by microvascular dysfunction in the blood vessels of skin, muscle, and nerve. We tested whether topical combinations aimed at improving mic... |
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Bicarbonate plays a critical role in the generation of cytotoxicity during SIN-1 decomposition in culture medium.
Oxid. Med. Cell. Longev. 2012 , 326731, (2012) 3-Morpholinosydnonimine (SIN-1) is used as a donor of peroxynitrite (ONOO(-)) in various studies. We demonstrated, however, that, the cell-culture medium remains cytotoxic to PC12 cells even after almost complete SIN-1 decomposition, suggesting that reaction ... |
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Loss of alpha-tocopherol upon exposure to nitric oxide or the sydnonimine SIN-1.
FEBS Lett. 315 , 139-142, (1993) SIN-1 which spontaneously decomposes to yield nitric oxide (NO.) and superoxide anion (O2.-) radicals caused a loss of microsomal alpha-tocopherol paralleled by the formation of alpha-tocopheryl quinone. The loss was partially prevented by superoxide dismutas... |
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Nitric oxide synthesis and action in an invertebrate brain.
Brain Res. 619 , 344-346, (1993) Nitric oxide (NO) is synthesized in mammalian neurons by Ca2+/calmodulin activated NO synthase and functions as a signalling molecule by activating soluble guanylyl cyclases in target cells. We demonstrate here that both NO synthase and NO-activated guanylyl ... |