U-69593
U-69593 structure
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Common Name | U-69593 | ||
|---|---|---|---|---|
| CAS Number | 96744-75-1 | Molecular Weight | 356.50 | |
| Density | 1.14g/cm3 | Boiling Point | 518.719ºC at 760 mmHg | |
| Molecular Formula | C22H32N2O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 267.512ºC | |
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Comparison of liquid chromatography-mass spectrometry and radioimmunoassay for measurement of fentanyl and determination of pharmacokinetics in equine plasma.
J. Anal. Toxicol. 32(9) , 754-9, (2008) This study evaluated the validity of measuring fentanyl concentrations in equine plasma using radioimmunoassay (RIA) by comparing it to the established technique of liquid chromatography-mass spectrometry (LC-MS). Equine plasma samples were analyzed using a s... |
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Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors.
J. Pharmacol. Exp. Ther. 346(3) , 545-54, (2013) In the mouse 55°C warm-water tail-withdrawal assay, a single administration of nor-binaltorphimine (nor-BNI; 10 mg/kg i.p.) antagonized κ-opioid receptor (KOR) agonist-induced antinociception up to 14 days, whereas naloxone (10 mg/kg i.p.)-mediated antagonism... |
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Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism.
J. Neurosci. 32(36) , 12325-36, (2012) Repeated stress releases dynorphins and causes subsequent activation of κ-opioid receptors (KORs) in limbic brain regions. The serotonergic dorsal raphe nucleus (DRN) has previously been found to be an important site of action for the dysphoric effects of dyn... |
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The effects of kappa-opioid receptor ligands on prepulse inhibition and CRF-induced prepulse inhibition deficits in the rat.
Psychopharmacology 210(2) , 231-40, (2010) Kappa-opioid receptor (KOR) agonists produce dysphoria and psychotomimesis in humans. KORs are enriched in the prefrontal cortex and other brain regions that regulate mood and cognitive function. Dysregulation of the dynorphin/KOR system has been implicated i... |
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Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways.
J. Neurochem. 107(6) , 1753-65, (2008) GTP binding regulatory protein (G protein)-coupled receptors can activate MAPK pathways via G protein-dependent and -independent mechanisms. However, the physiological outcomes correlated with the cellular signaling events are not as well characterized. In th... |
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Vagus nerve stimulation modulates visceral pain-related affective memory.
Behav. Brain Res. 236(1) , 8-15, (2013) Within a biopsychosocial model of pain, pain is seen as a conscious experience modulated by mental, emotional and sensory mechanisms. Recently, using a rodent visceral pain assay that combines the colorectal distension (CRD) model with the conditioned place a... |
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Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells.
J. Physiol. 589(Pt 14) , 3517-32, (2011) The dentate gyrus of the hippocampus is thought to control information flow into the rest of the hippocampus. Under pathological conditions, such as epilepsy, this protective feature is circumvented and uninhibited activity flows throughout the hippocampus. M... |
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Micro/kappa opioid interactions in rhesus monkeys: implications for analgesia and abuse liability.
Exp. Clin. Psychopharmacol. 16(5) , 386-99, (2008) Micro opioid receptor agonists are clinically valuable as analgesics; however, their use is limited by high abuse liability. Kappa opioid agonists also produce antinociception, but they do not produce micro agonist-like abuse-related effects, suggesting that ... |
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Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases.
J. Neurochem. 112(6) , 1431-41, (2010) As embryonic stem cell-derived neural progenitors (NPs) have the potential to be used in cell replacement therapy, an understanding of the signaling mechanisms that regulate their terminal differentiation is imperative. In previous studies, we discovered the ... |
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Effects of opioid receptor activation on thermal antinociception in red-eared slider turtles (Trachemys scripta).
Am. J. Vet. Res. 70(9) , 1072-8, (2009) To determine the effects of mu-, delta-, and kappa-opioid receptor (MOR, DOR, and KOR, respectively) activation on thermal antinociception in red-eared slider turtles Trachemys scripta.51 adult turtles.Infrared heat stimuli were applied to the plantar surface... |