Suplatast Tosilate
Suplatast Tosilate structure
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Common Name | Suplatast Tosilate | ||
|---|---|---|---|---|
| CAS Number | 94055-76-2 | Molecular Weight | 499.641 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H33NO7S2 | Melting Point | 84-87ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
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The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling.
Oncotarget 5(20) , 10070-83, (2014) Inappropriate activation of epidermal growth factor receptor (EGFR) plays a causal role in many cancers including colon cancer. The activation of EGFR by phosphorylation is balanced by receptor kinase and protein tyrosine phosphatase activities. However, the ... |
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Human JC virus small tumour antigen inhibits nucleotide excision repair and sensitises cells to DNA-damaging agents.
Mutagenesis 30 , 475-85, (2015) The human JC virus (JCV) is potentially carcinogenic to humans as a Group 2B carcinogen, and it is ubiquitous in human populations. To investigate whether the small tumour (ST) antigen of the JCV contributes to genomic instability, we established cell lines s... |
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Genetic characterization of German Mycobacterium avium strains isolated from different hosts and specimens by multilocus sequence typing.
Int. J. Med. Microbiol. 304(8) , 941-8, (2014) Infections caused by Mycobacterium avium and its subspecies are reported as emerging disease in many countries worldwide. In our study we applied the multilocus sequence typing technology to 98 German M. avium strains originating from different hosts and spec... |
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Rh protein expression in branchial neuroepithelial cells, and the role of ammonia in ventilatory control in fish.
Comp. Biochem. Physiol. A. Mol. Integr. Physiol. 186 , 39-51, (2015) Bill Milsom has made seminal contributions to our understanding of ventilatory control in a wide range of vertebrates. Teleosts are particularly interesting, because they produce a 3rd, potentially toxic respiratory gas (ammonia) in large amounts. Fish are we... |
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Inhibition of NOS-NO System Prevents Autoimmune Orchitis Development in Rats: Relevance of NO Released by Testicular Macrophages in Germ Cell Apoptosis and Testosterone Secretion.
PLoS ONE 10 , e0128709, (2015) Although the testis is considered an immunoprivileged organ it can orchestrate immune responses against pathological insults such as infection and trauma. Experimental autoimmune orchitis (EAO) is a model of chronic inflammation whose main histopathological f... |
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Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota.
Nat. Commun. 6 , 6495, (2015) Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the E... |
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Fucosylated surfactant protein-D is a biomarker candidate for the development of chronic obstructive pulmonary disease.
J. Proteomics 127 , 386-94, (2015) We previously reported that knockout mice for α1,6-fucosyltransferase (Fut8), which catalyzes the biosynthesis of core-fucose in N-glycans, develop emphysema and that Fut8 heterozygous knockout mice are more sensitive to cigarette smoke-induced emphysema than... |
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Foxp3+ regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen.
Eur. J. Immunol. 45(1) , 153-66, (2015) Regulatory T (Treg) cells are essential for maintaining self-tolerance and modulating inflammatory immune responses. Treg cells either develop within the thymus or are converted from CD4(+) naive T (Tnaive) cells in the periphery. The Treg-cell population siz... |
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Identifying best methods for routine ELISA detection of microcystin in seafood.
Environ. Monit. Assess. 187(2) , 12, (2015) Ingestion of water contaminated with the cyanotoxin, microcystin (MC), can pose serious health risks to humans. MC is also known to accumulate in seafood; however, this exposure pathway is much less understood. A fundamental element of this uncertainty is rel... |
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Genetic differentiation in the Mexican endemic Rufous-backed Robin, Turdus rufopalliatus (Passeriformes: Turdidae).
Zootaxa 4034 , 495-514, (2015) The Rufous-backed Robin (Turdus rufopalliatus) is endemic to deciduous and semideciduous tropical forests of western Mexico. Of the currently recognized subspecies, T. r. graysoni, from the Tres Marías Islands and nearby coastal Nayarit, has been considered a... |