(-)-Bilobalide
(-)-Bilobalide structure
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Common Name | (-)-Bilobalide | ||
|---|---|---|---|---|
| CAS Number | 33570-04-6 | Molecular Weight | 326.299 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 651.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H18O8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 247.5±25.0 °C | |
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Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.
Free Radic. Res. 48(10) , 1206-17, (2014) Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance, and other obesity related complications. So the hypoxia-s... |
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Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.
Magn. Reson. Chem. 50(8) , 569-75, (2012) The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, bilobalide, quercetin, kaempferol, isorh... |
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Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.
Toxicol. Sci. 139(2) , 338-49, (2014) Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex mixture with many constituents, including flavonol glycoside... |
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Neuroprotection by bilobalide in ischemia: improvement of mitochondrial function.
Pharmazie 68(7) , 584-9, (2013) Bilobalide, an active constituent of Ginkgo biloba, is known to have neuroprotective properties, but its mode of action remains unclear. In this study, bilobalide significantly reduced brain damage in mice (indicated by TTC staining) when given before transie... |
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Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
J. Agric. Food Chem. 59(20) , 10879-86, (2011) Codling moth, Cydia pomonella (L.), is a cosmopolitan pest of apple, potentially causing severe damage to the fruit. Currently used methods of combating this insect do not warrant full success or are harmful to the environment. The use of plant-derived semioc... |
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Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.
Mol. Pharmacol. 80 , 183-190, (2011) Bilobalide (BB), ginkgolide B (GB), diltiazem (DTZ), and picrotoxinin (PXN) are 5-hydroxytryptamine type 3 (5-HT(3)) receptor antagonists in which the principal sites of action are in the channel. To probe their exact binding locations, 5-HT(3) receptors with... |
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Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia.
Eur. J. Pharmacol. 677(1-3) , 71-6, (2012) Ginkgo biloba extracts show neuroprotective effects during cerebral ischemia, but with various components, the mechanisms of action remain unclear. In this study, we tested the effects of Ginkgolide B (GB) and bilobalide (BB) on normoglycemic and hyperglycemi... |
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Ginkgolides and bilobalide: their physical, chromatographic and spectroscopic properties.
Bioorg. Med. Chem. 13(17) , 5001-12, (2005) Ginkgolides A, B, C, J, K, L and M and bilobalide are rare terpene trilactones that have been isolated from leaves and root bark of the Chinese tree Ginkgo biloba. The structures of the highly oxidized ginkgolides were independently elucidated in the 1960s by... |
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Bilobalide and neuroprotection.
Pharmacol. Res. 46(6) , 565-8, (2002) In vivo studies have indicated that systemically administered bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba leaf extracts, can reduce cerebral edema produced by triethyltin, decrease cortical infarct volume in certain stroke models, and ... |
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[Gingkolides and bilobalide: structure, pharmacology, and synthesis].
Bioorg. Khim. 17(10) , 1301-12, (1991) The review summarizes data on the structure, pharmacology properties and synthetic investigations of ginkgolides and bilobalide occurring in the ginkgo tree (Ginkgo biloba L.). Ginkgolide B is a powerful antagonist of platelet activating factor. |