Ginkgolide B
Ginkgolide B structure
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Common Name | Ginkgolide B | ||
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| CAS Number | 15291-77-7 | Molecular Weight | 424.399 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 762.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C20H24O10 | Melting Point | 280°C (dec.) | |
| MSDS | USA | Flash Point | 274.3±26.4 °C | |
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Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.
Magn. Reson. Chem. 50(8) , 569-75, (2012) The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, bilobalide, quercetin, kaempferol, isorh... |
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Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.
Toxicol. Sci. 139(2) , 338-49, (2014) Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex mixture with many constituents, including flavonol glycoside... |
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Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.
J. Agric. Food Chem. 59(20) , 10879-86, (2011) Codling moth, Cydia pomonella (L.), is a cosmopolitan pest of apple, potentially causing severe damage to the fruit. Currently used methods of combating this insect do not warrant full success or are harmful to the environment. The use of plant-derived semioc... |
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Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro.
Med. Sci. Monit. 18(8) , BR293-298, (2012) Several HIV protease mutations, which are resistant to clinical HIV protease inhibitors (PIs), have been identified. There is a great need for second-generation PIs with different chemical structures and/or with an alternative mode of inhibition. Ginkgolic ac... |
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In vitro suppression of lymphocyte activation in patients with seasonal allergic rhinitis and pollen-related asthma by cetirizine or azelastine in combination with ginkgolide B or astaxanthin.
Acta Physiol. Hung. 99 , 173-184, (2012) Novel strategies are evaluated for management of allergic rhinitis and asthma in patients co-afflicted with both disorders. It is hypothesized that the platelet activating factor receptor antagonist ginkgolide B (GB) and the carotenoid antioxidant astaxanthin... |
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Ginkgolide B reduces atherogenesis and vascular inflammation in ApoE(-/-) mice.
PLoS ONE 7(5) , e36237, (2012) To investigate whether ginkgolide B (a platelet-activating factor inhibitor) affects vascular inflammation in atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice.Human platelets were used to evaluate the effects of ginkgolide B on platelet aggre... |
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Pharmacological action and mechanisms of ginkgolide B.
Chin. Med. J. 120(10) , 922-8, (2007) To review the recent research progress in pharmacological actions and mechanisms of ginkgolide B. Data sources Information included in this article was identified by searching of PUBMED (1987 - 2006) online resources using the key terms "ginkgolide B", "plate... |
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Therapeutic neuroprotective effects of ginkgolide B on cortex and basal ganglia in a rat model of transient focal ischemia.
Eur. J. Pharm. Sci. 44(3) , 235-40, (2011) Cerebral ischemia and reperfusion is one of the leading causes for death and severe disabilities in the world and often lead to irreversible brain damage over later lifespan. The aim of this study was to investigate the evolution of pathological damage in cer... |
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A novel anti-inflammatory role for ginkgolide B in asthma via inhibition of the ERK/MAPK signaling pathway.
Molecules 16(9) , 7634-48, (2011) Ginkgolide B is an anti-inflammatory extract of Ginkgo biloba and has been used therapeutically. It is a known inhibitor of platelet activating factor (PAF), which is important in the pathogenesis of asthma. Here, a non-infectious mouse model of asthma is use... |
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Premenstrual syndrome and migraine.
Neurol. Sci. 33 Suppl 1 , S111-5, (2012) Premenstrual syndrome (PMS) includes a wide variety of physical, psychological, and cognitive symptoms that occur recurrently and cyclically during the luteal phase of the menstrual cycle and disappear soon after the onset of menstruation. Headache, often of ... |