(+/-)8-HETE
(+/-)8-HETE structure
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Common Name | (+/-)8-HETE | ||
|---|---|---|---|---|
| CAS Number | 60934-46-5 | Molecular Weight | 554.65000 | |
| Density | N/A | Boiling Point | 615.3ºC at 760 mmHg | |
| Molecular Formula | C29H49Na2O5P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 325.9ºC | |
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Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants.
Bioorg. Med. Chem. 19 , 6348-55, (2011) The water-soluble vitamin E derivative, sodium dl-α-tocopheryl-6-O-phosphate (1), exhibits protective effects against skin damage. As reported herein, we investigated the actions of 1 on the formation of the inflammatory mediator, prostaglandin E(2) (PGE(2)),... |
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Analysis of vitamin E metabolites in biological specimen.
Mol. Nutr. Food. Res. 54(5) , 588-98, (2010) Vitamin E is known as the most important lipid antioxidant and is widely used to prevent age-associated diseases. Despite increasing knowledge about human vitamin E metabolism, little is known to justify its widespread use. As meta-analyses revealed even harm... |
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α-tocopherol and α-tocopheryl phosphate interact with the cannabinoid system in the rodent hippocampus.
Free Radic. Biol. Med. 51(9) , 1643-55, (2011) α-Tocopherol (α-TOH), a dietary component of vitamin E, is well known for its antioxidant capacity. Nevertheless, recent studies have pointed out non-anti-radical properties including cellular and genomic actions. Decreased levels of α-tocopherol in the brain... |
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α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse.
Free Radic. Biol. Med. 50(12) , 1794-800, (2011) α-Tocopheryl phosphate (α-TP), a water-soluble analogue of α-tocopherol, is found in humans, animals, and plants. α-TP is resistant to both acid and alkaline hydrolysis and may exert its own function in this form in vivo. In this study, the uptake, hydrolysis... |
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Vitamin E and cancer.
Nutr. Cancer 61(6) , 875-8, (2009) Protection by vitamin E against free radical-induced DNA mutations appears not to be an effective occurrence. On the other hand, in vitro evidence that different tocopherols slow down cell proliferation is an accepted observation. However, such an event may n... |
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Subchronic oral toxicity study of mixed tocopheryl phosphates in rats.
Int. J. Toxicol. 26(5) , 475-90, (2007) Rats were fed diets containing 0%, 1%, 3%, or 5% mixed tocopheryl phosphates for 90 days. No abnormal clinical signs related to treatment appeared. Some statistically significant changes in hematology and clinical chemistry parameters appeared, but the majori... |
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Differential effects of the ascorbyl and tocopheryl derivative on the methamphetamine-induced toxic behavior and toxicity.
Toxicology 240(1-2) , 96-110, (2007) A previous study showed that high doses of methamphetamine induce self-injurious behavior (SIB) in rodents. Furthermore, the combination of methamphetamine and morphine increased lethality in mice. We recently surmised that the rise in SIB and mortality induc... |
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Comparison of nitric oxide synthase inhibitors, phospholipase A2 inhibitor and free radical scavengers as attenuators of opioid withdrawal syndrome.
Behav. Pharmacol. 18(8) , 725-9, (2007) Chronic morphine-induced withdrawal syndrome after morphine cessation remains a severe obstacle in the clinical treatment of morphine. Previous studies have shown that nitric oxide synthetase (NOS) inhibitors may have therapeutic potential in morphine withdra... |
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alpha-tocopherol increases the intracellular glutathione level in HaCaT keratinocytes.
Free Radic. Res. 36(6) , 705-9, (2002) alpha-Tocopherol is a lipophilic vitamin that exhibits an antioxidative activity. The purpose of this study was to clarify the roles of alpha-tocopherol in the regulation of intracellular glutathione (GSH) levels in HaCaT keratinocytes. When HaCaT keratinocyt... |
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α-Tocopheryl phosphate--an activated form of vitamin E important for angiogenesis and vasculogenesis?
Biofactors 38(1) , 24-33, (2012) Vitamin E was originally discovered as a dietary factor essential for reproduction in rats. Since then, vitamin E has revealed many important molecular properties such as the scavenging of reactive oxygen and nitrogen species or the modulation of signal trans... |