MDL 12330A hydrochloride
MDL 12330A hydrochloride structure
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Common Name | MDL 12330A hydrochloride | ||
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| CAS Number | 40297-09-4 | Molecular Weight | 377.01 | |
| Density | N/A | Boiling Point | 515ºC at 760 mmHg | |
| Molecular Formula | C23H37ClN2 | Melting Point | 148 - 152 °C | |
| MSDS | USA | Flash Point | 265.2ºC | |
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Apparent PKA activity responds to intermittent hypoxia in bone cells: a redox pathway?
Am. J. Physiol. Heart Circ. Physiol. 299 , 225-35, (2010) We studied hypoxia-induced dynamic changes in the balance between PKA and PKA-counteracting phosphatases in the microfluidic environment in single cells using picosecond fluorescence spectroscopy and intramolecular fluorescence resonance energy transfer (FRET... |
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Stimulating effects of dopamine on chloride transport across the rat caudal epididymal epithelium in culture.
Biol. Reprod. 80(1) , 13-23, (2009) The present study investigated the effects of dopamine on chloride transport across cultured rat caudal epididymal epithelium. The results showed that dopamine induced a biphasic short-circuit current (Isc) in a concentration-dependent manner. The dopamine-in... |
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Dopamine D1 receptors mediate dopamine-induced duodenal epithelial ion transport in rats.
Transl. Res. 161(6) , 486-94, (2013) Dopamine (DA) is synthesized in gastrointestinal epithelial cells and performs important regulatory effects on the duodenal mucosa. However, the underlying mechanism remains largely unknown. The present study investigated the effect of DA on the duodenal epit... |
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Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster.
Eur. J. Neurosci. 28(10) , 1956-66, (2008) In gustatory receptor neurons (GRNs) in Drosophila melanogaster, Gr5a and one of the Gr64s encode sugar receptors with seven transmembrane domains. Previously, we have shown that the responses to various sugars are depressed in DGsalpha mutant flies (Ueno et ... |
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Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium.
PLoS ONE 8(1) , e54494, (2013) Recent studies suggest that formaldehyde (FA) could be synthesized endogeneously and transient receptor potential (TRP) channel might be the sensor of FA. However, the physiological significance is still unclear.The present study investigated the FA induced e... |
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Inhibitory effects of C4a on chemoattractant and secretagogue functions of the other anaphylatoxins via Gi protein-adenylyl cyclase inhibition pathway in mast cells.
Int. Immunopharmacol. 12(1) , 158-68, (2012) A recombinant complement anaphylatoxin, C4a, inhibited chemotaxis, respiratory burst and histamine release in mast cell-like HMC-1 cells that were treated with recombinant C5a anaphylatoxin. C4a also inhibited histamine release from HMC-1 cells that were indu... |
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CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells.
J. Vasc. Res. 47(2) , 148-56, (2010) ATP can activate several Ca(2+) influx channels in vascular endothelial cells. For example, it stimulates TRPC channels via capacitative and noncapacitative Ca(2+) entry (CCE and non-CCE, respectively) mechanisms; it also directly acts on P2X purinoceptors, r... |
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Adenosine receptor interactions alter cardiac contractility in rat heart.
Clin. Exp. Pharmacol. Physiol. 37(1) , 46-50, (2010) 1. The effect of the adenosine A(2) receptor (AdoA(2)R) agonist N(6)-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)-ethyl]adenosine (DPMA) on adenosine A(1) receptor (AdoA(1)R)-mediated negative inotropic responses was investigated in rat heart. 2. Hearts from m... |
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Developmental increase in D1-like dopamine receptor-mediated inhibition of glutamatergic transmission through P/Q-type channel regulation in the basal forebrain of rats.
Eur. J. Neurosci. 32(4) , 579-90, (2010) Whole-cell patch-clamp recordings of non-N-methyl-d-aspartate glutamatergic excitatory postsynaptic currents (EPSCs) were carried out from cholinergic neurons in slices of basal forebrain (BF) of developing rats aged 21-42 postnatal days to elucidate postnata... |
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Effects of scoparone on dopamine release in PC12 cells.
Fitoterapia 81(6) , 497-502, (2010) The effects of scoparone on dopamine release in PC12 cells were investigated. Scoparone at 50-200 microM increased dopamine release into the culture medium. However, the released levels of dopamine by scoparone were not altered in the absence of extracellular... |