Phorbol-12
Phorbol-12 structure
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Common Name | Phorbol-12 | ||
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| CAS Number | 37558-16-0 | Molecular Weight | 504.61200 | |
| Density | 1.27g/cm3 | Boiling Point | 623.4ºC at 760mmHg | |
| Molecular Formula | C28H40O8 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 199.3ºC | |
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A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors.
J. Biol. Chem. 290 , 14107-19, (2015) Anchoring proteins direct protein kinases and phosphoprotein phosphatases toward selected substrates to control the efficacy, context, and duration of neuronal phosphorylation events. The A-kinase anchoring protein AKAP79/150 interacts with protein kinase A (... |
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Charge density influences C1 domain ligand affinity and membrane interactions.
ChemBioChem. 15(8) , 1131-44, (2014) The C1 domain, which represents the recognition motif on protein kinase C for the lipophilic second messenger diacylglycerol and its ultrapotent analogues, the phorbol esters, has emerged as a promising therapeutic target for cancer and other indications. Pot... |
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Differential 12-O-Tetradecanoylphorbol-13-acetate-induced activation of rat mammary carcinoma susceptibility Fbxo10 variant promoters via a PKC-AP1 pathway.
Mol. Carcinog. 54(2) , 134-47, (2015) Rat mammary carcinoma susceptibility 5a1 (Mcs5a1), which is concordant to human MCS5A1 breast cancer risk locus, mediates susceptibility by a non-mammary cell-autonomous mechanism associated with T cell differential expression of F-box protein 10 (Fbxo10). Hu... |
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Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation.
J. Cell Biol. 210 , 771-83, (2015) Actin turnover in dendritic spines influences spine development, morphology, and plasticity, with functional consequences on learning and memory formation. In nonneuronal cells, protein kinase D (PKD) has an important role in stabilizing F-actin via multiple ... |
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Store-Operated Ca2+ Release-Activated Ca2+ Channels Regulate PAR2-Activated Ca2+ Signaling and Cytokine Production in Airway Epithelial Cells.
J. Immunol. 195 , 2122-33, (2015) The G-protein-coupled protease-activated receptor 2 (PAR2) plays an important role in the pathogenesis of various inflammatory and auto-immune disorders. In airway epithelial cells (AECs), stimulation of PAR2 by allergens and proteases triggers the release of... |
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Protein kinase C is a calcium sensor for presynaptic short-term plasticity.
Elife 3 , e03011, (2014) In presynaptic boutons, calcium (Ca(2+)) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca(2+) to their C2 domains, the proteins that sense sm... |
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Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner.
J. Cell Sci. 127(24) , 5179-88, (2014) The kinesin KIF1C is known to regulate podosomes, actin-rich adhesion structures that remodel the extracellular matrix during physiological processes. Here, we show that KIF1C is a player in the podosome-inducing signaling cascade. Upon induction of podosome ... |
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Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5.
Am. J. Physiol. Gastrointest. Liver Physiol. 309 , G703-15, (2015) Inappropriate activation of pattern recognition receptors has been described as a potential trigger in the development of inflammatory bowel disease (IBD). In this study, we evaluated the activity and expression of Na(+)/H(+) exchanger (NHE) subtypes in T84 i... |
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PKC-mediated cerebral vasoconstriction: Role of myosin light chain phosphorylation versus actin cytoskeleton reorganization.
Biochem. Pharmacol. 95 , 263-78, (2015) Defective protein kinase C (PKC) signaling has been suggested to contribute to abnormal vascular contraction in disease conditions including hypertension and diabetes. Our previous work on agonist and pressure-induced cerebral vasoconstriction implicated PKC ... |
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Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8⁺ T cells.
Sci. Signal. 7(348) , ra99, (2014) Protein kinase D2 (PKD2) is a serine and threonine kinase that is activated in T cells by diacylglycerol and protein kinase C in response to stimulation of the T cell receptor (TCR) by antigen. We quantified the activation of PKD2 at the single-cell level and... |