TRO 19622
TRO 19622 structure
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Common Name | TRO 19622 | ||
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| CAS Number | 22033-87-0 | Molecular Weight | 399.65200 | |
| Density | 1.1 | Boiling Point | 510ºC at 760mmHg | |
| Molecular Formula | C27H45NO | Melting Point | 145-148ºC | |
| MSDS | USA | Flash Point | 341ºC | |
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Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
J. Pharmacol. Exp. Ther. 322 , 709-720, (2007) Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive death of cortical and spinal motor neurons, for which there is no effective treatment. Using a cell-based assay for compounds capable of preventing motor ne... |
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The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation.
J. Neurosci. 31(1) , 359-70, (2011) Ablation of mouse occipital cortex induces precisely timed and uniform p53-modulated and Bax-dependent apoptosis of thalamocortical projection neurons in the dorsal lateral geniculate nucleus (LGN) by 7 d after lesion. We tested the hypothesis that this neuro... |
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Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy.
J. Pharmacol. Exp. Ther. 326(2) , 623-32, (2008) Diabetes and cancer chemotherapies are often associated with painful neuropathy. The mechanisms underlying neuropathic pain remain poorly understood, and the current therapies have limited efficacy and are associated with dose-limiting side effects. We recent... |
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TRO19622 promotes myelin repair in a rat model of demyelination.
Int. J. Neurosci. , (2013) Multiple sclerosis is a neurodegenerative autoimmune disease characterized by diffuse oligodendrocyte injury, axonal loss and multifocal demyelination of myelin sheaths in the central nervous system. TRO19622 is a small cholesterol-like compound, which displa... |
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Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes.
Toxicol. Appl. Pharmacol. 240(3) , 348-54, (2009) Thiazolidinediones (TZDs), such as troglitazone (TRO) and rosiglitazone (ROSI), improve insulin resistance by acting as ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma). TRO was withdrawn from the market because of... |