N6-Cyclohexyladenosine
N6-Cyclohexyladenosine structure
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Common Name | N6-Cyclohexyladenosine | ||
|---|---|---|---|---|
| CAS Number | 36396-99-3 | Molecular Weight | 349.38500 | |
| Density | 1.71g/cm3 | Boiling Point | 675.2ºC at 760mmHg | |
| Molecular Formula | C16H23N5O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 362.1ºC | |
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An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat.
Neuropharmacology 97 , 160-70, (2015) Adenosine kinase (AK) inhibitor is a potential candidate for controlling pain, but some AK inhibitors have problems of adverse effects such as motor impairment. ABT-702, a non-nucleoside AK inhibitor, shows analgesic effect in animal models of pain. Here, we ... |
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IL-6, A1 and A2aR: a crosstalk that modulates BDNF and induces neuroprotection.
Biochem. Biophys. Res. Commun. 449(4) , 477-82, (2014) Several diseases are related to retinal ganglion cell death, such as glaucoma, diabetes and other retinopathies. Many studies have attempted to identify factors that could increase neuroprotection after axotomy of these cells. Interleukin-6 has been shown to ... |
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The interaction of adenosine and morphine on pentylenetetrazole-induced seizure threshold in mice.
Neuropharmacology 72 , 1-8, (2013) Adenosine agonists or low doses of morphine exert anti-convulsant effects in different models of seizures. On the other hand, a tight interaction has been reported between morphine and adenosine in various paradigms. This study investigated the effect of the ... |
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The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
Pharmacol. Res. 56(2) , 110-7, (2007) In this research the role of adenosine A1 and A2A receptors of the entorhinal cortex on piriform cortex kindled seizures was investigated. In piriform cortex kindled rats, N6-cyclohexyladenosine (CHA), a selective A1 receptor agonist, 1,3-dimethyl-8 cyclopent... |
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Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats.
Neuropharmacology 56(8) , 1082-7, (2009) Modulation of glutamatergic neurotransmission by metabotropic glutamate2/3 (mGlu2/3) receptor agonists effectively treats seemingly diverse neuropsychiatric illness such as generalized anxiety disorder and schizophrenia. Activation of adenosine A(1) heterocep... |
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Adenosine A₂A and A₂B receptors are both required for adenosine A₁ receptor-mediated cardioprotection.
Am. J. Physiol. Heart Circ. Physiol. 301(3) , H1183-9, (2011) All four adenosine receptor subtypes have been shown to play a role in cardioprotection, and there is evidence that all four subtypes may be expressed in cardiomyocytes. There is also increasing evidence that optimal adenosine cardioprotection requires the ac... |
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Activation of adenosine₁ receptors induces antidepressant-like, anti-impulsive effects on differential reinforcement of low-rate 72-s behavior in rats.
J. Pharmacol. Exp. Ther. 341(2) , 564-70, (2012) Stress and psychiatric illness have been associated with a dysregulation of glutamatergic neurotransmission. Recently, positive allosteric modulators (PAMs) of the metabotropic glutamate 2 (mGlu₂) receptor have been found to exert antidepressant-like activity... |
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Up-regulation of adenosine A1 receptors in frontal cortex from Pick's disease cases.
Eur. J. Neurosci. 26(12) , 3501-8, (2007) The adenosine A(1) receptor (A(1)R)-adenylyl cyclase (AC) pathway was studied in post-mortem human frontal and occipital cortex from Pick's disease (PiD) cases and age-matched nondemented controls. In frontal cortex, the main brain area affected in PiD, A(1)R... |
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Central A1-receptor activation associated with onset of torpor protects the heart against low temperature in the Syrian hamster.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 295(3) , R991-6, (2008) Body temperature drops dramatically during hibernation, but the heart retains the ability to contract and is resistant to induction of arrhythmia. Although adaptive changes in the heart prior to hibernation may be involved in the cold-resistant property, it r... |
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Altered thermoregulation via sensitization of A1 adenosine receptors in dietary-restricted rats.
Psychopharmacology 209 , 217-24, (2010) Evidence links longevity to dietary restriction (DR). A decrease in body temperature (T(b)) is thought to contribute to enhanced longevity because lower T(b) reduces oxidative metabolism and oxidative stress. It is as yet unclear how DR decreases T(b).Here, w... |