Uridine monophosphate

Uridine monophosphate Structure
Uridine monophosphate structure
Common Name Uridine monophosphate
CAS Number 58-97-9 Molecular Weight 324.181
Density 2.2±0.1 g/cm3 Boiling Point 700.1±70.0 °C at 760 mmHg
Molecular Formula C9H13N2O9P Melting Point 202 ºC (decomp)
MSDS USA Flash Point 377.2±35.7 °C

Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray (Raja clavata) muscle.

J. Proteomics 128 , 458-68, (2015)

Thornback ray muscle hydrolysates (TRMHs) prepared by treatment with proteases from Bacillus subtilis A26 (TRMH-A26), Raja clavata crude alkaline protease extract (TRMH-Crude), Alcalase (TRMH-Alcalase) and Neutrase (TRMH-Neutrase) were elaborated and their an...

Clay catalyzed RNA synthesis under Martian conditions: Application for Mars return samples.

Biochem. Biophys. Res. Commun. 462 , 99-104, (2015)

Catalysis by montmorillonites clay minerals is regarded as a feasible mechanism for the abiotic production and polymerization of key biomolecules on early Earth. We have investigated a montmorillonite-catalyzed reaction of the 5'-phosphorimidazolide of nucleo...

Pyrimidine homeostasis is accomplished by directed overflow metabolism.

Nature 500(7461) , 237-41, (2013)

Cellular metabolism converts available nutrients into usable energy and biomass precursors. The process is regulated to facilitate efficient nutrient use and metabolic homeostasis. Feedback inhibition of the first committed step of a pathway by its final prod...

Comprehensive quantitative analysis of purines and pyrimidines in the human malaria parasite using ion-pairing ultra-performance liquid chromatography-mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 967 , 127-33, (2014)

Targeted metabolite profiling has aided in the understanding of a variety of biological processes in the malaria parasite as well as in drug discovery. A fast and sensitive analytical method, based on ion-pairing reversed phase ultra-high performance liquid c...

Isolation and identification of Vibrio toranzoniae associated with diseased red conger eel (Genypterus chilensis) farmed in Chile.

Vet. Microbiol. 179 , 327-31, (2015)

The present study deals with the first isolation of Vibrio toranzoniae from cultured red conger eel (Genypterus chilensis). During the summer season of 2011, mortalities were observed in young red conger eel at one aquaculture experimental rearing system in Q...

A model for transcription initiation in human mitochondria.

Nucleic Acids Res. 43 , 3726-35, (2015)

Regulation of transcription of mtDNA is thought to be crucial for maintenance of redox potential and vitality of the cell but is poorly understood at the molecular level. In this study we mapped the binding sites of the core transcription initiation factors T...

Nucleoside/nucleotide analogue polymerase inhibitors in development.

Clin. Liver Dis. 17(1) , 105-10, (2013)

Nucleoside/nucleotide analogue polymerase inhibitors (NPIs) are analogues of natural substrates that bind the active site of NS5B and terminate viral RNA chain generation and generally provide a high genetic barrier to resistance and are effective in all geno...

PDE7A1 hydrolyzes cCMP.

FEBS Lett. 588(18) , 3469-74, (2014)

The degradation and biological role of the cyclic pyrimidine nucleotide cCMP is largely elusive. We investigated nucleoside 3',5'-cyclic monophosphate (cNMP) specificity of six different recombinant phosphodiesterases (PDEs) by using a highly-sensitive HPLC-M...

Site-directed mutagenesis studies on the uridine monophosphate binding sites of feedback inhibition in carbamoyl phosphate synthetase and effects on cytidine production by Bacillus amyloliquefaciens.

Can. J. Microbiol. 59(6) , 374-9, (2013)

A major problem when pyrimidine de novo biosynthesis is used for cytidine production is the existence of many negative regulatory factors. Cytidine biosynthesis in Bacillus amyloliquefaciens proceeds via a pathway that is controlled by uridine monophosphate (...

Cost-effectiveness of sofosbuvir-based triple therapy for untreated patients with genotype 1 chronic hepatitis C.

Hepatology 59(5) , 1692-705, (2014)

We assessed the cost-effectiveness of sofosbuvir (SOF)-based triple therapy (TT) compared with boceprevir (BOC)- and telaprevir (TVR)-based TT in untreated genotype 1 (G1) chronic hepatitis C (CHC) patients discriminated according to IL28B genotype, severity ...