SR 48692
SR 48692 structure
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Common Name | SR 48692 | ||
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| CAS Number | 146362-70-1 | Molecular Weight | 587.065 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 781.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C32H31ClN4O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 426.2±32.9 °C | |
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Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement.
J. Pharmacol. Exp. Ther. 325(2) , 556-66, (2008) Cocaine-primed reinstatement is an animal model of drug relapse. The neurocircuitry underlying cocaine-primed reinstatement includes a decrease in GABA in the ventral pallidum (VP) that is inhibited by a mu opioid receptor antagonist, suggesting that opioid p... |
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Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.
J. Neurosci. 33(18) , 7618-26, (2013) The lateral hypothalamus (LH) sends a dense glutamatergic and peptidergic projection to dopamine neurons in the ventral tegmental area (VTA), a cell group known to promote reinforcement and aspects of reward. The role of the LH to VTA projection in reward-see... |
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The role of neurotensin in positive reinforcement in the rat central nucleus of amygdala.
Behav. Brain Res. 208(2) , 430-5, (2010) In the central nervous system neurotensin (NT) acts as a neurotransmitter and neuromodulator. It was shown that NT has positive reinforcing effects after its direct microinjection into the ventral tegmental area. The central nucleus of amygdala (CeA), part of... |
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Neurotensin modulation of acetylcholine, GABA, and aspartate release from rat prefrontal cortex studied in vivo with microdialysis.
Brain Res. Bull. 77(2-3) , 129-35, (2008) The effects of the peptide transmitter neurotensin (NT) on the release of acetylcholine (ACh), gamma-aminobutyric acid (GABA), glutamate (Glu), aspartate (Asp), and taurine from the prefrontal cortex (PFC) of freely moving rats were studied by transversal mic... |
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Electrophysiological effects of neurotensin on globus pallidus neurons of 6-hydroxydopamine-lesioned rats.
Neurosci. Res. 17 , 153-61, (2009) The globus pallidus is a nucleus in the indirect pathway of the basal ganglia circuits. Neurotensin has been reported to play an important role in the central nervous system. Functional study revealed that systemic administration of neurotensin produced antip... |
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Stimulation by neurotensin of dopamine and 5-hydroxytryptamine (5-HT) release from rat prefrontal cortex: possible role of NTR1 receptors in neuropsychiatric disorders.
Neurochem. Int. 53(6-8) , 355-61, (2008) The modulation of cortical dopaminergic and serotonergic neurotransmissions by neurotensin (NT) was studied by measuring the release of dopamine (DA) and 5-hydroxytryptamine (5-HT) from the prefrontal cortex (PFC) of freely moving rats. The samples were colle... |
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The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.
Bioorg. Med. Chem. Lett. 19(5) , 1438-41, (2009) In a search for nonpeptide agonists for the neurotensin receptor (NTR1), we replaced the adamantyl amino acid moiety found in the antagonist SR48692 (1a) with leucine and related alpha-alkylamino acids found in peptide agonists. When tested in a calcium mobil... |
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Pancreatic cancer bears overexpression of neurotensin and neurotensin receptor subtype-1 and SR 48692 counteracts neurotensin induced cell proliferation in human pancreatic ductal carcinoma cell line PANC-1.
Neuropeptides 45(2) , 151-6, (2011) The presence of neurotensin and neurotensin receptors has been demonstrated in human pancreatic carcinomas using autoradiography and Northern blot analysis. In vitro studies have reported that the neurotensin antagonist SR 48692 could inhibit the growth of MI... |
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Intra-accumbens shell injections of SR48692 enhanced cocaine self-administration intake in rats exposed to an environmentally-elicited reinstatement paradigm.
Brain Res. 1280 , 124-36, (2009) Neurotensin (NT) is a neuropeptide involved in cocaine reward, and in learning and memory processes related to drug use within the mesolimbic dopamine (DA) system. Studies have demonstrated that NT receptor antagonists have potential as pharmacotherapeutical ... |
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High-affinity neurotensin receptor is involved in phosphoinositide turnover increase by inhibition of sodium pump in neonatal rat brain.
Neurochem. Res. 33(11) , 2206-13, (2008) Phosphoinositide (PI) metabolism is enhanced in neonatal brain by activation of neurotransmitter receptors and by inhibition of the sodium pump with ouabain or endogenous inhibitor termed endobain E. Peptide neurotensin inhibits synaptosomal membrane Na(+), K... |