1,3-DIPROPYL-8-P-SULFOPHENYLXANTHINE
1,3-DIPROPYL-8-P-SULFOPHENYLXANTHINE structure
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Common Name | 1,3-DIPROPYL-8-P-SULFOPHENYLXANTHINE | ||
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| CAS Number | 89073-57-4 | Molecular Weight | 392.43000 | |
| Density | 1.405g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C17H20N4O5S | Melting Point | >300ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Extracellular 2',3'-cAMP-adenosine pathway in proximal tubular, thick ascending limb, and collecting duct epithelial cells.
Am. J. Physiol. Renal Physiol. 304(1) , F49-55, (2013) In a previous study, we demonstrated that human proximal tubular epithelial cells obtained from a commercial source metabolized extracellular 2',3'-cAMP to 2'-AMP and 3'-AMP and extracellular 2'-AMP and 3'-AMP to adenosine (the extracellular 2',3'-cAMP-adenos... |
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Expression of the 2',3'-cAMP-adenosine pathway in astrocytes and microglia.
J. Neurochem. 118 , 979-987, (2011) Many organs express the extracellular 3',5'-cAMP-adenosine pathway (conversion of extracellular 3',5'-cAMP to 5'-AMP and 5'-AMP to adenosine). Some organs release 2',3'-cAMP (isomer of 3',5'-cAMP) and convert extracellular 2',3'-cAMP to 2'- and 3'-AMP and con... |
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Sustained reduction in myocardial reperfusion injury with an adenosine receptor antagonist: possible role of the neutrophil chemoattractant response.
J. Pharmacol. Exp. Ther. 292(3) , 929-38, (2000) Recent studies have demonstrated that three membrane-permeant A(1) receptor antagonists reduced infarct size in a model of ischemia followed by brief reperfusion. However, it was not determined whether cardioprotection was mediated by nonspecific intracellula... |
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Interaction of carbon monoxide and adenosine in the nucleus tractus solitarii of rats.
Hypertension 42(3) , 380-5, (2003) Carbon monoxide has been identified as an endogenous biological messenger in the brain. Heme oxygenase catalyzes the metabolism of heme to carbon monoxide and biliverdin. Previously, we have shown the involvement of carbon monoxide in central cardiovascular r... |
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Angiotensin converting enzyme inhibition prevents trophic and hypertensive effects of an antagonist of adenosine receptors.
Eur. J. Pharmacol. 441(1-2) , 99-104, (2002) The continuous infusion of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), a non-selective antagonist of adenosine receptors, causes hypertension and marked cardiovascular structural changes in Wistar rats. Adenosine inhibits noradrenaline and renin release. We i... |
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The role of angiotensin II in hypertension due to adenosine receptors blockade.
Eur. J. Pharmacol. 455(2-3) , 135-41, (2002) The renin-angiotensin system may be involved in hypertension induced by adenosine receptors blockade with 1,3-dipropyl-8-sulfophenylxanthine (DPSPX). Contractions of the mesenteric vasculature to angiotensin II, noradrenaline and potassium chloride were studi... |
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Role of A1 receptors in renal sympathetic neurotransmission in the mouse kidney.
Am. J. Physiol. Renal Physiol. 303(7) , F1000-5, (2012) A(1) receptors may participate in renal sympathetic neurotransmission by enhancing the postjunctional effects of norepinephrine. The purpose of this study was to test this concept using A(1) receptor knockout (A(1)AR-/-) mice. In isolated kidneys from nontran... |
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Modulation of catecholamine release by endogenous adenosine in the rat adrenal medulla.
J. Biomed. Sci. 8(5) , 389-94, (2001) Adenosine was shown to inhibit norepinephrine (NE) release from sympathetic nerve endings. The purpose of this study was to examine whether endogenous adenosine restrains NE and epinephrine release from the adrenal medulla. The effects of an adenosine recepto... |
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Scavenging of nitric oxide by an antagonist of adenosine receptors.
J. Pharm. Pharmacol. 57(3) , 399-404, (2005) Chronic treatment of rats with 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), an antagonist of adenosine receptors, causes hypertension, cardiovascular hypertrophy and hyperplasia and impaired endothelium-dependent vasodilatation. An accelerated degradation of n... |
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Pre- and postjunctional effects of angiotensin II in hypertension due to adenosine receptor blockade.
Eur. J. Pharmacol. 531(1-3) , 209-16, (2006) Prejunctional facilitation of [3H]noradrenaline release induced by sympathetic nerve stimulation and postjunctional contractile effects of angiotensin II were studied in the mesenteric artery and vein of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX)-hypertensive... |