8-Aminooctanoic acid
8-Aminooctanoic acid structure
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Common Name | 8-Aminooctanoic acid | ||
|---|---|---|---|---|
| CAS Number | 1002-57-9 | Molecular Weight | 159.226 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 286.0±23.0 °C at 760 mmHg | |
| Molecular Formula | C8H17NO2 | Melting Point | 194 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 126.8±22.6 °C | |
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Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid.
J. Med. Chem. 48 , 6741-9, (2005) Improving cellular uptake and biodistribution remains one of the major obstacles for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics. Recently, we reported the identification and functional characterization of an a... |
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Surface interactions of a homologous series of alpha,omega-amino acids on colloidal silver and gold.
Biospectroscopy 5(1) , 9-17, (1999) Surface enhanced Raman spectroscopy (SERS) was used to characterize a homologous series of alpha,omega-amino acids on colloidal gold and silver. Raman and SER spectra of the alpha,omega-amino acids, NH2(CH2)nCOOH (n = 3-7), are presented and analyzed, reveali... |
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Covalent complexes between serum albumin and 7-hydroxycoumarin-4-acetic acid: synthesis and applications in the spectrophotometric detection of long-chain fatty acids.
Biochim. Biophys. Acta 1304(1) , 43-55, (1996) Using a hydrophobic 8-aminooctanoic acid cross-linker, the pH-indicator dye 7-hydroxycoumarin-4-acetic acid (7-HCA) is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups. A highly stable and water-soluble complex (BSA-HCA... |
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In vivo imaging of mesenchymal-epithelial transition factor (c-Met) expression using an optical imaging system.
Bioconjug. Chem. 20(7) , 1299-306, (2009) Mesenchymal-epithelial transition factor (c-Met) is a receptor tyrosine kinase that has been shown to be overexpressed and mutated in a variety of malignancies, such as glioma. We have recently found that an (125)I-radiolabeled Gly-Gly-Gly (GGG)- or 8-aminooc... |
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NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity.
BMC Chem. Biol. 10 , 2, (2010) NAD+ is a coenzyme for hydride transfer enzymes and a substrate for sirtuins and other NAD+-dependent ADPribose transfer enzymes. In wild-type Saccharomyces cerevisiae, calorie restriction accomplished by glucose limitation extends replicative lifespan in a m... |
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Introduction of an 8-aminooctanoic acid linker enhances uptake of 99mTc-labeled lactam bridge-cyclized α-MSH peptide in melanoma.
J. Nucl. Med. 55(12) , 2057-63, (2014) The purpose of this study was to examine the effects of amino acid, hydrocarbon, and polyethylene glycol (PEG) linkers on the melanoma targeting and imaging properties of (99m)Tc-labeled lactam bridge-cyclized HYNIC-linker-Nle-CycMSHhex (hydrazinonicotinamide... |
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Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7-14)NH2 structural paradigm in a prostate cancer model.
Bioconjug. Chem. 19(9) , 1803-12, (2008) The high incidence of BB2 receptor (BB2r) expression in various cancers has prompted investigators to pursue the development of BB2r-targeted agents for diagnostic imaging, chemotherapy, and radiotherapy. Development of BB2r-targeted agents, based on the bomb... |
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In vitro and in vivo evaluation of a64Cu-labeled NOTA-Bn-SCN-Aoc-bombesin analogue in gastrin-releasing peptide receptor expressing prostate cancer
Nucl. Med. Biol. 39(5) , 609-16, (2012) Introduction Bombesin (BN) is an amphibian peptide that binds to the gastrin-releasing peptide receptor (GRPR). It has been demonstrated that BN analogues can be radiolabeled for potential diagnosis and treatment of GRPR-expressing malignancies. Previous stud... |
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Characterization, biodistribution and small-animal SPECT of I-125-labeled c-Met binding peptide in mice bearing c-Met receptor tyrosine kinase-positive tumor xenografts.
Nucl. Med. Biol. 36(4) , 371-8, (2009) c-Met is a receptor tyrosine kinase involved in tumor cell growth, invasion, metastases and angiogenesis. Overexpression of c-Met is frequently observed in several tumor types. Here, we report the in vitro cell-binding properties and biodistribution and SPECT... |
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The gamma-aminobutyric acid-mimetic action of omega-aminocaprylic acid in rat cortex.
Neurosci. Lett. 57(3) , 295-9, (1985) The 8-carbon chain analogue of gamma-aminobutyric acid (GABA), omega-aminocaprylic acid (omega-AC), was administered to single cortical neurones of rat by microiontophoresis and its effect on cell firing compared to the effect elicited by GABA. The spontaneou... |