8-(3-Chlorostyryl)caffeine
8-(3-Chlorostyryl)caffeine structure
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Common Name | 8-(3-Chlorostyryl)caffeine | ||
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| CAS Number | 147700-11-6 | Molecular Weight | 330.76900 | |
| Density | 1.36g/cm3 | Boiling Point | 559.4ºC at 760 mmHg | |
| Molecular Formula | C16H15ClN4O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 292.1ºC | |
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Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia.
PLoS ONE 8(2) , e57065, (2013) Achieving a prolonged neuroprotective state following transient ischemic attacks (TIAs) is likely to effectively reduce the brain damage and neurological dysfunction associated with recurrent stroke. HPC is a phenomenon in which advanced exposure to mild hypo... |
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Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats.
Neurotox. Res. 21 , 222-30, (2011) A(2A) adenosine receptor antagonists have been proposed as a new therapy of PD. Since oxidative stress plays an important role in the pathogenesis of PD, we studied the effect of the selective A(2A) adenosine receptor antagonists 8-(-3-chlorostyryl)caffeine (... |
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Vinegar intake enhances flow-mediated vasodilatation via upregulation of endothelial nitric oxide synthase activity.
Biosci. Biotechnol. Biochem. 74 , 1055-61, (2010) This study examined the effect of acetate on endothelial nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs) by immunoblotting assay and the ability of acetic acid to upregulate flow-mediated vasodilatation in humans. In HUVECs, ac... |
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Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists.
J. Med. Chem. 36 , 1333-1342, (1993) A series of substituted 8-styryl derivatives of 1,3,7-alkylxanthines was synthesized as potential A2-selective adenosine receptor antagonists, and the potency at rat brain A1- and A2-receptors was studied in radioligand binding experiments. At the xanthine 7-... |
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8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo.
FEBS Lett. 323 , 141-144, (1993) An adenosine antagonist, 8-(3-chlorostyryl)caffeine (CSC), was shown previously to be 520-fold selective for A2a-adenosine receptors in radioligand binding assays in the rat brain. In reversing agonist effects on adenylate cyclase, CSC was 22-fold selective f... |