MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)-
![MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)- Structure](https://image.chemsrc.com/caspic/127/53177-12-1.png)
MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)- structure
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Common Name | MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)- | ||
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| CAS Number | 53177-12-1 | Molecular Weight | 356.686 | |
| Density | N/A | Boiling Point | 448.8ºC at 760mmHg | |
| Molecular Formula | C16H14ClMnN2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 294.1ºC | |
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Asymmetric epoxidation of unfunctionalized alkenes catalyzed by sugar moiety-modified chiral salen-Mn(III) complexes.
Carbohydr. Res. 344(1) , 61-6, (2009) Several chiral Schiff-base ligands with sugar moieties at C-3 (3') or C-5 (5') of salicylaldehyde were synthesized from reaction of salicylaldehyde derivatives with diamine. These ligands coordinated with Mn(III) to afford the corresponding chiral salen-Mn(II... |
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Fluorimetric study of the pro-oxidant activity of EUK8 in the presence of hydrogen peroxide.
Biometals 21(4) , 425-32, (2008) The catalase mimetic complex Mn(III)-salen chloride (EUK8) was found to be pro-oxidant under low hydrogen peroxide concentrations. The increase in the fluorescence rate of the probe 1,2,3-dihydrorhodamine (DHR) in solution, as well as the carbonyl content of ... |
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Role of superoxide dismutase enzymes and ascorbate in protection of nitrergic relaxation against superoxide anions in mouse duodenum.
Acta Pharmacol. Sin. 29(6) , 687-97, (2008) The aim of this study was to investigate whether superoxide dismutase (SOD) enzymes and ascorbate play a role in the protection of the nitrergic relaxation against superoxide anion inhibition in the mouse duodenum.The effects of exogenous SOD, N,No-bis(salicy... |
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DNA binding, antioxidant activity, and DNA damage protection of chiral macrocyclic Mn(III) salen complexes.
Chirality 24(12) , 1063-73, (2012) We are reporting the synthesis, characterization, and calf thymus DNA binding studies of novel chiral macrocyclic Mn(III) salen complexes S-1, R-1, S-2, and R-2. These chiral complexes showed ability to bind with DNA, where complex S-1 exhibits the highest DN... |
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Salen-manganese complexes: sophisticated tools for the analysis of intercellular ROS signaling pathways.
Anticancer Res. 30(10) , 3967-79, (2010) Salen-manganese complexes, such as EUK-8 and EUK-134 are known as catalase mimetics with superoxide dismutase (SOD) and peroxidase mimetic activity. Here we show that the concentration-dependent use of salen-manganese complexes within the appropriate time win... |
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Structure-activity relationship of 15 different Mn-salen derivatives against free radicals.
Drug Chem. Toxicol. 36(1) , 9-18, (2013) Increased levels of reactive oxygen species (ROS) play a vital role in the pathogenesis of various diseases. Thus, antioxidants would play pivotal roles in the therapy of ROS-induced diseases. Regarding this fact, in the present study, we compared the relativ... |
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Mitochondrial protection and the reversal of left ventricular remodeling.
Circ. J. 73(11) , 2017-8, (2009)
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Salen Mn complexes mitigate radiation injury in normal tissues.
Anticancer Agents Med. Chem. 11(4) , 359-72, (2011) Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injur... |
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Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.
Circ. J. 73(11) , 2125-34, (2009) Mice lacking manganese-superoxide dismutase (Mn-SOD) activity exhibit the typical pathology of dilated cardiomyopathy (DCM). In the present study, presymptomatic and symptomatic mutant mice were treated with the SOD/catalase mimetic, EUK-8.Presymptomatic hear... |
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Prooxidant activity of the superoxide dismutase (SOD)-mimetic EUK-8 in proliferating and growth-arrestedEscherichia colicells
Free Radic. Biol. Med. 45 , 708-715, (2008) Numerous studies have aimed to alleviate oxidative stress in a wide range of organisms by increasing superoxide dismutase (SOD) activity. However, experimental approaches have yielded contradictory evidence, and kinetics models have shown that increases in SO... |