Cytochrome C
Cytochrome C structure
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Common Name | Cytochrome C | ||
|---|---|---|---|---|
| CAS Number | 9007-43-6 | Molecular Weight | 884.887 | |
| Density | N/A | Boiling Point | 1323.5ºC at 760 mmHg | |
| Molecular Formula | C42H52FeN8O6S2 | Melting Point | 300ºC | |
| MSDS | Chinese USA | Flash Point | 754.2ºC | |
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Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring.
Toxicol. Lett. 228(2) , 85-92, (2014) An emerging literature suggests that bisphenol A (BPA), a widespread endocrine disrupting chemical, when exposure occurs in early life, may increase the risk of metabolic syndrome. In this study, we investigated the hypothesis that perinatal exposure to BPA p... |
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Involvement of CaM-CaMKII-ERK in bisphenol A-induced Sertoli cell apoptosis.
Toxicology 324 , 27-34, (2014) Bisphenol A (BPA), one of the most prevalent chemicals for daily use, has been reported as a xenoestrogen to induce reproductive toxicity, but its mechanism is poorly understood. In the present study, we aimed to explore whether CaM-CaMKII-ERK1/2 signaling pa... |
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Assessment of cytochrome C oxidase dysfunction in the substantia nigra/ventral tegmental area in schizophrenia.
PLoS ONE 9(6) , e100054, (2014) Perturbations in metabolism are a well-documented but complex facet of schizophrenia pathology. Optimal cellular performance requires the proper functioning of the electron transport chain, which is constituted by four enzymes located within the inner membran... |
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The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling.
Biochem. J. 463(1) , 41-52, (2014) Parkinson's disease is characterized by the progressive and selective loss of dopaminergic neurons in the substantia nigra. It has been postulated that endogenously formed CysDA (5-S-cysteinyldopamine) and its metabolites may be, in part, responsible for this... |
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Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.
Chem. Biol. Interact. 218 , 1-9, (2014) Myristicin, an allylbenzene, is a major active component of various spices, such as nutmeg and cinnamon, plants from the Umbelliferae family or in some essential oils, such as oils of clove or marjoram. Human exposure to myristicin is low but widespread due t... |
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Propofol protects against nitrosative stress-induced apoptotic insults to cerebrovascular endothelial cells via an intrinsic mitochondrial mechanism.
Surgery 154(1) , 58-68, (2013) Cerebrovascular endothelial cells (CECs), major component cells of the blood-brain barrier, can be injured by oxidative stress. Propofol can protect cells from oxidative injury. The aim of this study was to evaluate the effects of propofol on nitrosative stre... |
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Cytotoxic, pro-apoptotic, pro-oxidant, and non-genotoxic activities of a novel copper(II) complex against human cervical cancer.
Toxicology 314(1) , 155-65, (2013) Cisplatin remains one of the most effective current chemotherapeutic agents; however, metal complexes synthesis has increased in order to produce new anti-neoplastic drugs with DNA binding and apoptotic activities in tumor cells and less toxicity for patients... |
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Mitochondrial bioenergetics deregulation caused by long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies in rat brain: a possible role of mPTP opening as a pathomechanism in these disorders?
Biochim. Biophys. Acta 1842(9) , 1658-67, (2014) Long-chain 3-hydroxylated fatty acids (LCHFA) accumulate in long-chain 3-hydroxy-acyl-CoA dehydrogenase (LCHAD) and mitochondrial trifunctional protein (MTP) deficiencies. Affected patients usually present severe neonatal symptoms involving cardiac and hepati... |
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Cytotoxicity and genotoxicity of chlorhexidine on macrophages in vitro.
Environ. Toxicol. 29(4) , 452-8, (2014) Chlorhexidine (CHX) is the most widely used antiseptic for wound, skin disinfection, and dental hygiene. The aim of this study is to investigate the possible correlation between CHX-induced cytogenotoxicity and alterations in normal cell cycle on RAW264.7 mac... |
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Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(1) , R26-34, (2014) Changes in the maternal nutritional environment during fetal development can influence offspring's metabolic risk in later life. Animal models have demonstrated that offspring of diet-induced obese dams develop metabolic complications, including nonalcoholic ... |