H-D-Trp-OMe.HCl
H-D-Trp-OMe.HCl structure
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Common Name | H-D-Trp-OMe.HCl | ||
|---|---|---|---|---|
| CAS Number | 14907-27-8 | Molecular Weight | 254.713 | |
| Density | N/A | Boiling Point | 390.6ºC at 760mmHg | |
| Molecular Formula | C12H15ClN2O2 | Melting Point | 213-216ºC | |
| MSDS | Chinese USA | Flash Point | 190ºC | |
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Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.
Infect. Immun. 79 , 4425-4437, (2011) Gamma interferon (IFN-γ) induces expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial cells, the permissive cells for the obligate intracellular bacterium Chlamydia trachomatis. IDO1 depletes tryptophan by ca... |
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Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia.
J. Obstet. Gynaecol. Res. 34(1) , 1-6, (2008) We have previously demonstrated that mRNA expression and enzyme activity levels of placental indoleamine 2,3-dioxygenase (IDO), which degrades L-tryptophan and blocks the proliferation of T cells, are significantly low in patients with severe pre-eclampsia. F... |
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Abnormal brain tryptophan metabolism and clinical correlates in Tourette syndrome.
Mov. Disord 22(15) , 2256-62, (2007) Symptoms in Tourette syndrome (TS) are likely related to abnormalities involving multiple neurotransmitter systems in striatal-thalamo-cortical circuitry. Although prior studies have found abnormal levels of tryptophan, serotonin, and their metabolites in blo... |
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Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy.
Epilepsia 49(8) , 1419-30, (2008) The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood-brain barrier (BBB) and of concentrating in the epileptogenic tissues of acute and chronic animal models of temporal lobe epilepsy to render these tissues ... |
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Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate.
Transpl. Immunol. 20(1-2) , 55-60, (2008) The induction of tolerance towards allogeneic solid organ grafts is one of the major goals in transplantation medicine. Mesenchymal stem cells (MSC) inhibit the immune response in vitro, and thus are promising candidate cells to promote acceptance of transpla... |
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Tumor immune escape mediated by indoleamine 2,3-dioxygenase.
Immunol. Lett. 111(2) , 69-75, (2007) Amongst the numerous mediators contributing towards the escape of tumors from the host's immune response against them, the enzyme indoleamine 2,3-dioxygenase (IDO) has recently attracted special attention. By catabolizing tryptophan to N-formyl-kynurenine, ID... |
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Cis-diastereoselectivity in pictet-spengler reactions of L-tryptophan and electronic circular dichroism studies.
Chirality 24(10) , 789-95, (2012) The diastereoselective synthesis of optically active 1,3-disubstituted tetrahydro-β-carbolines using polar protic Pictet-Spengler cyclization of (S)-tryptophan methyl ester with five aldehydes RCHO (R═CH(3), C(2)H(5), C(3)H(7), C(4)H(9), and C(6)H(5)) was stu... |
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Can diffusion tensor imaging (DTI) identify epileptogenic tubers in tuberous sclerosis complex? Correlation with α-[11C]methyl-L-tryptophan ([11C] AMT) positron emission tomography (PET).
J. Child Neurol. 27(5) , 598-603, (2012) In this study, we determined whether diffusion tensor imaging (DTI), a more widely available imaging modality, is as effective as α-[(11)C]methyl-l-tryptophan (AMT)-positron emission tomography (PET) in localizing epileptogenic tubers in tuberous sclerosis co... |
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Preclinical evaluation of HIV eradication strategies in the simian immunodeficiency virus-infected rhesus macaque: a pilot study testing inhibition of indoleamine 2,3-dioxygenase.
AIDS Res. Hum. Retroviruses 29(2) , 207-14, (2013) Even in the setting of maximally suppressive antiretroviral therapy (ART), HIV persists indefinitely. Several mechanisms might contribute to this persistence, including chronic inflammation and immune dysfunction. In this study, we have explored a preclinical... |
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99mTc-DTPA-amino acids conjugate as specific SPECT pharmaceuticals for tumor imaging.
Chem. Biol. Drug Des. 74(2) , 159-64, (2009) (99m)Tc-Diethylene triamine pentaacetic acid-bis (amide) conjugates have been synthesized and evaluated as a potential radiopharmaceutical for tumor imaging. The compounds were synthesized by the condensation reaction of DTPA bis(anhydride) with different l-a... |