L-Norvaline
L-Norvaline structure
|
Common Name | L-Norvaline | ||
|---|---|---|---|---|
| CAS Number | 6600-40-4 | Molecular Weight | 117.146 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 222.9±23.0 °C at 760 mmHg | |
| Molecular Formula | C5H11NO2 | Melting Point | 300ºC | |
| MSDS | Chinese USA | Flash Point | 88.6±22.6 °C | |
|
Detection of ethanolamine altering in fetuses of pregnancy-associated hypertensive mice treated with vasodepressors by using UPLC and MALDI-TOF/MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1006 , 93-8, (2015) Since serotonin, homocysteine and oxytocin are known to fluctuate during mammalian gestation, we screened amines altered in pregnant-associated hypertensive (PAH) mice by tagging their amino groups with 6-aminoquinoline carbamoyl (AQC) group in concert with u... |
|
|
Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1).
Bioorg. Med. Chem. 19 , 6409-18, (2011) The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been... |
|
|
Aminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguity.
Nucleic Acids Res. 41(21) , 9825-38, (2013) Aminoacyl-tRNA synthetases should ensure high accuracy in tRNA aminoacylation. However, the absence of significant structural differences between amino acids always poses a direct challenge for some aminoacyl-tRNA synthetases, such as leucyl-tRNA synthetase (... |
|
|
An evolutionary strategy for isobutanol production strain development inEscherichia coli
Metab. Eng. 13(6) , 674-81, (2011) Higher alcohols such as isobutanol possess several physical characteristics that make them attractive as biofuels such as higher energy densities and infrastructure compatibility. Here we have developed a rapid evolutionary strategy for isolating strains of E... |
|
|
[Overproduction of noncanonical amino acids by Escherichia coli cells].
Mikrobiologiia 76(6) , 805-12, (2007) Overproduction of noncanonical amino acids norvaline and norleucine by Escherichia coli with inactivated acetohydroxy acid synthases was demonstrated. The cultivation conditions for the overproduction of noncanonical amino acids were studied. The effect of th... |
|
|
Hypothalamic food intake regulation in a cancer-cachectic mouse model.
J. Cachexia. Sarcopenia Muscle 5(2) , 159-69, (2014) Appetite is frequently affected in cancer patients leading to anorexia and consequently insufficient food intake. In this study, we report on hypothalamic gene expression profile of a cancer-cachectic mouse model with increased food intake. In this model, mic... |
|
|
The specificity and kinetic mechanism of branched-chain amino acid aminotransferase from Escherichia coli studied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis.
FEBS J. 281(1) , 391-400, (2014) Branched-chain amino acid aminotransferase (BCAT) plays a key role in the biosynthesis of hydrophobic amino acids (such as leucine, isoleucine and valine), and its substrate spectrum has not been fully explored or exploited owing to the inescapable restrictio... |
|
|
A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.
FEBS J. 278(17) , 3140-51, (2011) Bovine glutamate dehydrogenase is potently inhibited by zinc and the major impact is on V(max) suggesting a V-type effect on catalysis or product release. Zinc inhibition decreases as glutamate concentrations decrease suggesting a role for subunit interaction... |
|
|
A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity.
J. Med. Chem. 53 , 1038-47, (2010) The objective of the present study was to identify a camptothecin (CPT) prodrug with optimal release and cytotoxicity properties for immobilization on a passively targeted microparticle delivery system. A series of alpha-amino acid ester prodrugs of CPT were ... |
|
|
Metabolome analysis of gram-positive bacteria such as Staphylococcus aureus by GC-MS and LC-MS.
Methods Mol. Biol. 815 , 377-98, (2012) The field of metabolomics has become increasingly important in the context of functional genomics. Together with other "omics" data, the investigation of the metabolome is an essential part of systems biology. Beside the analysis of human and animal biofluids... |