H-Glu(OtBu)-OtBu.HCl
H-Glu(OtBu)-OtBu.HCl structure
|
Common Name | H-Glu(OtBu)-OtBu.HCl | ||
|---|---|---|---|---|
| CAS Number | 32677-01-3 | Molecular Weight | 295.803 | |
| Density | 1.02g/cm3 | Boiling Point | 311.1ºC at 760 mmHg | |
| Molecular Formula | C13H26ClNO4 | Melting Point | 60 to 75ºC | |
| MSDS | USA | Flash Point | 78.1ºC | |
|
Synthesis and biological activity of analogues of the C-terminal hexapeptide of substance P with modifications at glutaminyl and methioninyl residues. Structure-activity studies.
Int. J. Pept. Protein Res. 40 , 395-400, (1992) Analogues of [Orn6]-SP6-11 have been synthesized in which the methionyl residue is replaced by glutamine gamma-carboxamide substituted derivatives. These analogues where tested in three in vitro preparations representative of NK-1, NK-2 and NK-3 receptor type... |
|
|
Synthesis of potent antagonists of substance P by modifying the methionyl and glutaminyl residues of its C-terminal hexapeptide and without using D-amino acids.
Int. J. Pept. Protein Res. 41 , 411-414, (1993) Analogues of [Orn6]-SP6-11 have been synthesized in which the Met11-NH2 residue is replaced by the alpha, gamma-dimethyl, alpha, gamma-dibenzyl and alpha, gamma-di-tert-butyl esters of glutamic acid. These analogues were tested in three in vitro preparations ... |
|
|
Convulsant properties of L-glutamic acid di-tert butyl ester.
Neurobehav. Toxicol. Teratol. 7 , 275-278, (1985) Glutamic acid di-tert butyl ester (GTBE) was found to have a pronounced convulsant effect in mice and rats, producing recurrent clonic convulsions combined with postural and respiratory disturbances in a dosage of 0.5 mmol/kg (148 mg/kg). Tert-butyl ester der... |