Glutathione-monoethyl ester (reduced)
Glutathione-monoethyl ester (reduced) structure
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Common Name | Glutathione-monoethyl ester (reduced) | ||
|---|---|---|---|---|
| CAS Number | 92614-59-0 | Molecular Weight | 335.38 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 644.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C12H21N3O6S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 343.5±31.5 °C | |
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PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance.
Blood 124(10) , 1626-36, (2014) The aim of this study was to assess the efficiency of p53 reactivation and induction of massive apoptosis (PRIMA-1(Met)) in inducing myeloma cell death, using 27 human myeloma cell lines (HMCLs) and 23 primary samples. Measuring the lethal dose (LD50) of HMCL... |
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Dual-targeting of aberrant glucose metabolism in glioblastoma.
J. Exp. Clin. Cancer Res 34 , 14, (2015) Glioblastoma (GBM) is the most common and malignant primary brain tumor. In contrast to some other tumor types, aberrant glucose metabolism is an important component of GBM growth and chemoresistance. Recent studies of human orthotopic GBM in mice and in situ... |
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Fibroblasts that resist cigarette smoke-induced senescence acquire profibrotic phenotypes.
Am. J. Physiol. Lung Cell. Mol. Physiol. 307(5) , L364-73, (2014) This study assessed the effect of extended exposure to cigarette smoke extract (CSE) on tissue repair functions in lung fibroblasts. Human fetal (HFL-1) and adult lung fibroblasts were exposed to CSE for 14 days. Senescence-associated β-galactosidase (SA β-ga... |
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Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB.
Biochem. Pharmacol. 62 , 787-794, (2001) The airway epithelium is injured by oxidants inhaled as atmospheric pollutants or produced during inflammatory responses. We studied the effect of modulating the antioxidant intracellular glutathione, both using thiol compounds and by the adaptive effect of h... |
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Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.
Arch. Biochem. Biophys. 239 , 538, (1985) Glutathione monoethyl ester (L-gamma-glutamyl-L-cysteinylglycyl ethyl ester), in contrast to glutathione itself, is effectively transported into many types of cells. The ester is converted intracellularly into glutathione. Intraperitoneal injection of 35S-lab... |
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Glutathione monoesters.
Anal. Biochem. 183 , 16, (1989) Glutathione monoesters in which the glycine carboxyl group is esterified are effective cellular glutathione delivery agents because they are readily transported into cells and are deesterified intracellularly. In contrast, glutathione itself is not effectivel... |
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Blood cell oxidative stress precedes hemolysis in whole blood–liver slice co-cultures of rat, dog, and human tissues
Toxicol. Appl. Pharmacol. 244 , 354-65, (2010) A novel in vitro model to investigate time-dependent and concentration-dependent responses in blood cells and hemolytic events is studied for rat, dog, and human tissues. Whole blood is co-cultured with a precision-cut liver slice. Methimazole (MMI) was selec... |
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Glutathione monoethyl ester: high-performance liquid chromatographic analysis and direct preparation of the free base form.
Anal. Biochem. 183 , 21, (1989) Glutathione monoethyl ester (L-gamma-glutamyl-L-cysteinylglycine ethyl ester) was shown by R. N. Puri and A. Meister (1983, Proc. Natl. Acad. Sci. USA 80, 5258-5260) to be taken up by several tissues and intracellularly hydrolyzed to GSH. Since GSH itself is ... |
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Rescue from neonatal death in the murine model of hereditary tyrosinemia by glutathione monoethylester and vitamin C treatment.
Mol. Genet. Metab. 93 , 306-313, (2008) Hereditary tyrosinemia type 1 (HT1) is a recessive disease caused by a deficiency of the enzyme fumarylacetoacetate hydrolase (FAH) that catalyzes the conversion of fumarylacetoacetate (FAA) into fumarate and acetoacetate. In mice models of HT1, FAH deficienc... |
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Specialized protective role of mucosal glutathione in pigmented rabbit conjunctiva.
Invest. Ophthalmol. Vis. Sci. 44 , 4427-4438, (2003) To investigate mechanisms of H(2)O(2)-induced reduction in rates of active ion transport (I(sc)) across the pigmented rabbit conjunctival tissue and the protective role afforded by mucosal glutathione (GSH).Changes in I(sc) and specific binding properties of ... |