8-PHENYLTHEOPHYLLINE
8-PHENYLTHEOPHYLLINE structure
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Common Name | 8-PHENYLTHEOPHYLLINE | ||
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| CAS Number | 961-45-5 | Molecular Weight | 256.26000 | |
| Density | 1.361g/cm3 | Boiling Point | 517.7ºC at 760mmHg | |
| Molecular Formula | C13H12N4O2 | Melting Point | >300ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 266.9ºC | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Effects of A2BR on the biological behavior of mouse renal fibroblasts during hypoxia.
Mol. Med. Report. 11 , 4397-402, (2015) Fibroblasts are the effector cells of collagen secretion in renal interstitial fibrosis (RIF), and their proliferation and activation are essential for the development of RIF. Hypoxic ischemia in local tissues has been identified in chronic kidney diseases (C... |
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Opposing effects of ATP and adenosine on barrier function of rat coronary microvasculature.
J. Mol. Cell. Cardiol. 52(5) , 962-70, (2012) ATP can differentially affect the micro- and macrovascular endothelial barrier. It has been shown that it can both increase and/or decrease macromolecule permeability of microvascular endothelial cells and microvessels, in vivo. We hypothesised that the barri... |
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Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.
Mol. Pharmacol. 29 , 331, (1986) [3H]NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuronamide) is known to bind to both the A1 and A2 subtypes of adenosine receptor in rat striatal membranes. In order to study the putative A2 component of [3H]NECA binding, we examined several co... |
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Synthesis of selective SRPK-1 inhibitors: novel tricyclic quinoxaline derivatives.
Bioorg. Med. Chem. Lett. 15 , 3241-6, (2005) SR protein-specific kinase-1 (SRPK-1) has been identified as a validated target for hepatitis B virus (HBV). A series of novel tricyclic quinoxaline derivatives was designed and synthesised as potential kinase inhibitory antiviral agents and was found to be a... |
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Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation.
Cell Commun. Signal. 11 , 70, (2013) Chronic musculoskeletal pain involves connective tissue remodeling triggered by inflammatory mediators, such as bradykinin. Fibroblast cells signaling involve changes in intracellular Ca2+ ([Ca2+]i). ATP has been related to connective tissue mechanotransducti... |
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Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats.
Hepatology 44(4) , 813-22, (2006) Acute liver injury is associated with renal insufficiency, whose mechanism may be related to activation of the hepatorenal reflex. We previously showed that intrahepatic adenosine is involved in activation of the hepatorenal reflex to restrict urine productio... |
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Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.
Curr. Drug Saf. 4(2) , 97-102, (2009) The effects exerted by P1 and P2 as well as by A1 and A2 agonists and antagonists purinoceptor on the acute opiate withdrawal induced by morphine were investigated in vitro. Following a 4 min in vitro exposure to morphine, the guinea-pig isolated ileum exhibi... |
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Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition.
J. Physiol. Pharmacol. 58 Suppl 5(Pt 1) , 95-103, (2007) Recent evidence suggests that theophylline, apart from bronchodilatation, derives its therapeutic activity in asthma from anti-inflammatory effects. Free oxygen radicals play important role in the perpetuation of inflammatory processes underlying bronchoconst... |
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Changes in atrium and thoracic aorta reactivity to adenosinergic and adrenergic agonists in experimental hyperhomocysteinemia.
J. Cardiovasc. Pharmacol. 47(5) , 673-9, (2006) We prepared diet-induced hyperhomocysteinemia (hHcy) in adult male Wistar rats and investigated the effects of hHcy on the adenosinergic and adrenergic responses in vitro and in vivo. The responsiveness of right atria from hHcy rats to the negative chronotrop... |