Olomoucine
Olomoucine structure
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Common Name | Olomoucine | ||
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| CAS Number | 101622-51-9 | Molecular Weight | 298.343 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 579.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C15H18N6O | Melting Point | 120-130 °C | |
| MSDS | Chinese USA | Flash Point | 304.3±32.9 °C | |
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Inhibition of cyclin-dependent kinases by purine analogues.
Eur. J. Biochem. 224 , 771, (1994) While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylami... |
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Steering neuronal growth cones by shifting the imbalance between exocytosis and endocytosis.
J. Neurosci. 34(21) , 7165-78, (2014) Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across the growth cone that mediates its attractive or repulsive ... |
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Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.
Biol. Cell 83 , 105-120, (1995) Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kin... |
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Downregulation of gastrokine-1 in gastric cancer tissues and restoration of its expression induced gastric cancer cells to apoptosis.
J. Exp. Clin. Cancer Res 31 , 49, (2012) Gastrokine-1 (GKN1), a secreted protein, is specifically expressed in gastric mucosa to protect and maintain the integrity of gastric epithelium. The present study investigated differential expression of GKN1 in normal, precancerous, and cancerous gastric tis... |
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The Cdk5 inhibitor olomoucine promotes corneal debridement wound closure in vivo.
Mol. Vis. 14 , 542-9, (2008) To investigate the effect of the Cdk5 inhibitor olomoucine on corneal debridement wound healing in vivo.Corneal debridement wounds of 1.5 mm were made on the ocular surface of CD-1 mice. A 20 microl drop of 15 microM olomoucine in 1% DMSO was applied to the w... |