Calphostin C
Calphostin C structure
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Common Name | Calphostin C | ||
|---|---|---|---|---|
| CAS Number | 121263-19-2 | Molecular Weight | 790.764 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 1039.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C44H38O14 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 317.0±27.8 °C | |
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β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.
J. Biol. Chem. 288(43) , 31370-85, (2013) The adenylyl cyclase activator forskolin facilitates synaptic transmission presynaptically via cAMP-dependent protein kinase (PKA). In addition, cAMP also increases glutamate release via PKA-independent mechanisms, although the downstream presynaptic targets ... |
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PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity.
Circ. Res. 111(11) , 1446-58, (2012) Activation of peroxisome proliferator-activated receptor-γ (PPARγ) by thiazolidinediones lowers blood pressure, whereas PPARγ mutations cause hypertension. Previous studies suggest these effects may be mediated through the vasculature, but the underlying mech... |
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Impairment of neurovascular coupling in type 1 diabetes mellitus in rats is linked to PKC modulation of BK(Ca) and Kir channels.
Am. J. Physiol. Heart Circ. Physiol. 302(6) , H1274-84, (2012) We hypothesized that chronic hyperglycemia has a detrimental effect on neurovascular coupling in the brain and that this may be linked to protein kinase C (PKC)-mediated phosphorylation. Therefore, in a rat model of streptozotocin-induced chronic type 1 diabe... |
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Upregulation of macrophage-specific functions by oxidized LDL: lysosomal degradation-dependent and -independent pathways.
Mol. Cell Biochem. 372(1-2) , 181-90, (2013) Formation of foam cells from macrophages, which are formed by the differentiation of blood-borne monocytes, is a critical early event in atherogenesis. To examine how pre-exposure of monocytes to modified proteins, such as oxLDL, influences their differentiat... |
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Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine.
Mol. Cells 35(1) , 79-86, (2013) Interstitial cells of Cajal (ICC) are the pacemaker cells that generate the rhythmic oscillation responsible for the production of slow waves in gastrointestinal smooth muscle. Spingolipids are known to present in digestive system and are responsible for mult... |
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Insulin targets the Na(+)/K(+) ATPase in enterocytes via PI3K, PKC, and MAPKS.
J. Recept. Signal Transduct. Res. 31(4) , 299-306, (2011) The effect of insulin on intestinal Na(+)/K(+) ATPase is till now undetermined, and it is still unclear whether insulin exerts any modulatory effect on glucose absorption by targeting the ATPase. This work attempted to address this question and to unravel the... |
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Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria.
Br. J. Haematol. 152(5) , 631-9, (2011) Thrombosis in paroxysmal nocturnal haemoglobinuria (PNH) has been suggested to be due to several pathophysiological states: a suppressed fibrinolytic system, increased leucocyte-derived tissue factor, complement (C')-mediated damage to platelets and endotheli... |
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Potassium 2-(1-hydroxypentyl)-benzoate attenuated hydrogen peroxide-induced apoptosis in neuroblastoma SK-N-SH cells.
Eur. J. Pharmacol. 680(1-3) , 49-54, (2012) Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB) has been shown to have potent neuroprotective effects, such as reducing the infarct volume and improving neurobehavioral deficits in the transient focal cerebral ischemic rat model. The present study is to eval... |
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PKC-dependent phosphorylation of p27 at T198 contributes to p27 stabilization and cell cycle arrest.
Cell Cycle 11(8) , 1583-92, (2012) In this manuscript, we present experimental evidence that PKCs phosphorylate p27 at T198 in vitro and in vivo, resulting in p27 stabilization and cell cycle arrest in MCF-7 and HeLa cells. Our findings indicate that (1) recombinant PKCα, βII, δ, η and θ isofo... |
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Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes.
Br. J. Anaesth. 107(4) , 510-8, (2011) Desflurane triggers post-conditioning in the diabetic human myocardium. We determined whether protein kinase C (PKC), mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) channels, Akt, and glycogen synthase kinase-3β (GSK-3β) were involved i... |