Spermine NONOate
Spermine NONOate structure
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Common Name | Spermine NONOate | ||
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| CAS Number | 136587-13-8 | Molecular Weight | 262.352 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 425.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C10H26N6O2 | Melting Point | 105-107ºC | |
| MSDS | USA | Flash Point | 211.1±31.5 °C | |
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The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.
Oncogene 34(14) , 1799-810, (2015) Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular m... |
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Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.
Plant Mol. Biol. 81(1-2) , 27-40, (2013) Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone layers. The inducible expressions of α-Amy2/54 and α-amylas... |
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S-Nitrosylation of NF-κB p65 Inhibits TSH-Induced Na(+)/I(-) Symporter Expression.
Endocrinology 156 , 4741-54, (2015) Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide variety of cellular physiological processes. In thyroid cells, NO-synthase III-endogenously produced NO reduces TSH-stimulated thyroid-specific gene expression, suggesting a potential aut... |
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Nitric oxide enhances keratinocyte cell migration by regulating Rho GTPase via cGMP-PKG signalling.
PLoS ONE 10(3) , e0121551, (2015) Nitric oxide (NO) has been shown to improve wound healing, but the mechanism underlying this function is not well defined. Here, we explored the effect of NO on the migration of a human keratinocyte cell line (HaCaT) and its possible mechanism.The effects of ... |
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Cross-linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species.
J. Neurosci. Res. 90(6) , 1218-29, (2012) Serine racemase (SR) is the only identified enzyme in mammals responsible for isomerization of L-serine to D-serine, a coagonist at N-methyl-D-aspartate (NMDA) receptors in the forebrain. Our previous data showed that an apparent SR dimer resistant to sodium ... |
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Control of intracellular Francisella tularensis by different cell types and the role of nitric oxide.
J. Immunol. Res. 2014 , 694717, (2014) Reactive nitrogen is critical for the clearance of Francisella tularensis infections. Here we assess the role of nitric oxide in control of intracellular infections in two murine macrophage cell lines of different provenance: the alveolar macrophage cell line... |
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Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5.
Med. Sci. Monit. 17(5) , CR241-7, (2011) Within erythrocytes (RBCs), cAMP levels are regulated by phosphodiesterases (PDEs). Increases in cAMP and ATP release associated with activation of β-adrenergic receptors (βARs) and prostacyclin receptors (IPRs) are regulated by PDEs 2, 4 and PDE 3, respectiv... |
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Inefficient translation of nsrR constrains behaviour of the NsrR regulon in Escherichia coli.
Microbiology 161 , 2029-38, (2015) The NsrR protein of Escherichia coli is a transcriptional repressor that contains an [Fe-S] cluster that is the binding site for nitric oxide (NO). Reaction of NsrR with NO leads to de-repression of its target genes, which include those encoding an NO scaveng... |
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Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland during experimentally induced mastitis in vivo and in vitro.
Domest. Anim. Endocrinol. 52 , 90-9, (2015) The aim of the study was to determine the effects of lipopolysaccharide (LPS), tumor necrosis factor alpha (TNF), interleukin-1-alpha (IL-1α), and nitric oxide donor (NONOate) on both in vivo and in vitro secretion of prostaglandin (PG)E2, PGF2α, leukotriene ... |
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Complexes of nitric oxide with nucleophiles as agents for the controlled biological release of nitric oxide: hemodynamic effect in the rabbit.
J. Cardiovasc. Pharmacol. 22 , 287, (1993) Nitric oxide (NO) and drugs that generate NO are potent vasodilators. We investigated the in vivo vasodilator potential of a unique group of compounds that release NO spontaneously in solution, the NO/nucleophile complexes. The hemodynamic effects of diethyla... |