GW5074
GW5074 structure
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Common Name | GW5074 | ||
|---|---|---|---|---|
| CAS Number | 220904-83-6 | Molecular Weight | 520.942 | |
| Density | 2.2±0.1 g/cm3 | Boiling Point | 561.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H8Br2INO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 293.3±30.1 °C | |
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Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2.
Biochim. Biophys. Acta 1853 , 1606-14, (2015) Rotenone (ROT) is a widely used inhibitor of complex I (CI), the first complex of the mitochondrial oxidative phosphorylation (OXPHOS) system. However, particularly at high concentrations ROT was also described to display off-target effects. Here we studied h... |
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Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.
J. Immunol. 194(4) , 1856-66, (2015) During secondary immune responses, Ab-opsonized bacteria are efficiently taken up via FcRs by dendritic cells. We now demonstrate that this process induces cross-talk between FcRs and TLRs, which results in synergistic release of several inflammatory cytokine... |
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Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.
Hum. Mol. Genet. 23(23) , 6212-22, (2014) Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson's disease (PD) and contribute to sporadic PD. LRRK2 contains Guanosine-5'-triphosphate (GTP) binding, GTPase and kinase activities that have been implicated in the n... |
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Berberine up-regulates hepatic low-density lipoprotein receptor through Ras-independent but AMP-activated protein kinase-dependent Raf-1 activation.
Biol. Pharm. Bull. 37(11) , 1766-75, (2014) Our previous studies showed that berberine (BBR) increases liver low-density lipoprotein (LDL) receptor expression in an extracellular signal-regulated kinase (ERK)-dependent manner. This study was designed to explore the upstream cellular signaling molecules... |
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Ouabain elicits human glioblastoma cells apoptosis by generating reactive oxygen species in ERK-p66SHC-dependent pathway.
Mol. Cell Biochem. 398(1-2) , 95-104, (2015) Excessive reactive oxygen species (ROS) generation has been implicated as one of main agents in ouabain-induced anticancer effect. Unfortunately, the signaling pathways under it are not very clarified. In the present study, we investigated the molecular mecha... |
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Spontaneously hyperactive MEK-Erk pathway mediates paradoxical facilitation of cell proliferation in mild hypoxia.
Biochim. Biophys. Acta 1850(4) , 640-6, (2015) Oxygen is important for common eukaryotic cells to generate ATP. Pathophysiological conditions such as ischemic diseases cause tissue hypoxia. In addition, oxygen availability in deep tissues is supposed to be far lower than surrounding atmosphere even in hea... |
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Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression.
Int. Immunopharmacol. 29 , 15-20, (2015) Corneal epithelial erosion is one of the most common problems in clinical ophthalmology. Despite significant progress in understanding how the cornea heals, clinically available pharmacological therapies that can promote repair and prevent visual complication... |
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MAPK signaling triggers transcriptional induction of cFOS during amino acid limitation of HepG2 cells.
Biochim. Biophys. Acta 1854(3) , 539-48, (2015) Amino acid (AA) deprivation in mammalian cells activates a collection of signaling cascades known as the AA response (AAR), which is characterized by transcriptional induction of stress-related genes, including FBJ murine osteosarcoma viral oncogene homolog (... |
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Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.
J. Pharmacol. Exp. Ther. 330(3) , 810-7, (2009) Studies have shown that long-term (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol (morphine) treatment increases the sensitivity to painful heat stimuli (thermal hyperalgesia). The cellular adaptations contributing to sustained morphine-me... |
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DA-9801 promotes neurite outgrowth via ERK1/2-CREB pathway in PC12 cells.
Biol. Pharm. Bull. 38(2) , 169-78, (2015) In the present study, we examined the mechanisms underlying the effect of DA-9801 on neurite outgrowth. We found that DA-9801 elicits its effects via the mitogen-activated protein kinase (MEK) extracellular signal-regulated kinase (ERK)1/2-cAMP response eleme... |