guanosine-3',5'-cyclic monophosphorothioate, sp-isomer sodium salt
guanosine-3',5'-cyclic monophosphorothioate, sp-isomer sodium salt structure
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Common Name | guanosine-3',5'-cyclic monophosphorothioate, sp-isomer sodium salt | ||
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| CAS Number | 86562-10-9 | Molecular Weight | 462.46100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H27N6O6PS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'-monophosphorothioates.
FEBS Lett. 263 , 47-50, (1990) The activation of the cGMP-dependent protein kinase and cAMP-dependent protein kinase by the diastereomers of guanosine 3',5'-monophosphorothioate, (Sp)-cGMPS and (Rp)-cGMPS, and 8-chloroguanosine 3',5'-monophosphorothioate, (Sp)-8-Cl-cGMPS and (Rp)-8-Cl-cGMP... |
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Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase.
Proc. Natl. Acad. Sci. U. S. A. 91 , 7583-7587, (1994) Nitric oxide (NO)-induced relaxation is associated with increased levels of cGMP in vascular smooth muscle cells. However, the mechanism by which cGMP causes relaxation is unknown. This study tested the hypothesis that activation of Ca-sensitive K (KCa) chann... |
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