Octreotide acetate
Octreotide acetate structure
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Common Name | Octreotide acetate | ||
|---|---|---|---|---|
| CAS Number | 83150-76-9 | Molecular Weight | 1019.239 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1447.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C49H66N10O10S2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 829.1±34.3 °C | |
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Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.
J. Neurosci. 34(35) , 11769-80, (2014) Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hippocampus onto septal cells, and are therefore likely to als... |
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Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics.
Am. J. Physiol. Endocrinol. Metab. 308(5) , E426-33, (2015) The objective of this study was to assess the insulin-independent effects of incretin hormones on glucose and glycerol metabolism and hemodynamics under euglycemic and hyperglycemic conditions. Young, healthy men (n=10) underwent three trials in a randomized,... |
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Evaluation of cobalt-labeled octreotide analogs for molecular imaging and auger electron-based radionuclide therapy.
J. Nucl. Med. 55(8) , 1311-6, (2015) The somatostatin receptor, which is overexpressed by many neuroendocrine tumors, is a well-known target for molecular imaging and peptide receptor radionuclide therapy. Recently, (57)Co-labeled DOTATOC, an octreotide analog, was shown to have the highest affi... |
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Quantitative imaging of a therapeutic peptide in biological tissue sections by MALDI MS.
Bioanalysis 5(5) , 603-12, (2013) Therapeutic peptides and proteins are being increasingly explored as potential therapeutic agents for molecular-targeted therapy, and the requirement for quantitative bioanalytical tools for such molecules has been discussed.The distribution of octreotide, a ... |
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Combined derivatization and high-performance liquid chromatography with fluorescence and ultraviolet detection for simultaneous analysis of octreotide and gabexate mesylate metabolite in human pancreatic juice samples.
Biomed. Chromatogr. 29 , 911-7, (2015) A simple and sensitive method based on the combination of derivatization and high-performance liquid chromatography with ultraviolet and fluorimetric detection was developed for the simultaneous determination of octreotide and gabexate mesylate metabolite in ... |
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Identification and Assessment of Octreotide Acylation in Polyester Microspheres by LC-MS/MS.
Pharm. Res. 32 , 3044-54, (2015) Polyesters with hydrophilic domains, i.e., poly(D,L-lactic-co-glycolic-co-hydroxymethyl glycolic acid) (PLGHMGA) and a multiblock copolymer of poly(ε-caprolactone)-PEG-poly(ε-caprolactone) and poly(L-lactide) ((PC-PEG-PC)-(PL)) are expected to cause less acyl... |
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Octreotide inhibits the bilirubin carriers organic anion transporting polypeptides 1B1 and 1B3 and the multidrug resistance-associated protein 2.
J. Pharmacol. Exp. Ther. 355 , 145-51, (2015) The somatostatin analog octreotide can lead to hyperbilirubinemia without evidence of liver injury. Here we investigate whether octreotide inhibits the main sinusoidal/canalicular bilirubin carriers and whether it is a transport substrate. Octreotide showed t... |
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Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression.
J. Physiol. 593(5) , 1239-57, (2015) Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity. This is particularly relevant to older people who are less active, sarcopaenic and at increased risk of statin myalgia. We hypothesised that statin myal... |
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Docetaxel in combination with octreotide shows synergistic apoptotic effect by increasing SSTR2 and SSTR5 expression levels in prostate and breast cancer cell lines.
Cancer Chemother. Pharmacol. 75 , 1273-80, (2015) Docetaxel (DTX) is widely used for the treatment of metastatic prostate and breast cancers. Despite the clinical success of DTX, drug-related cumulative toxicity restricts its clinical use in cancer therapy. Thus, there is an urgent need for new therapeutic o... |
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A novel suspension formulation enhances intestinal absorption of macromolecules via transient and reversible transport mechanisms.
Pharm. Res. 31(8) , 2010-21, (2014) Medium chain fatty acid salts promote absorption by increasing paracellular permeability of the intestinal epithelium. Novel oily suspension (OS) formulation disperses a powder containing sodium caprylate and macromolecules such as octreotide or fluorescent d... |