Orotidine
Orotidine structure
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Common Name | Orotidine | ||
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| CAS Number | 314-50-1 | Molecular Weight | 288.211 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C10H12N2O8 | Melting Point | 200ºC | |
| MSDS | USA | Flash Point | N/A | |
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Pyrophosphate interactions at the transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases.
J. Am. Chem. Soc. 132(25) , 8787-94, (2010) Orotate phosphoribosyltransferases from Plasmodium falciparum and human sources (PfOPRT and HsOPRT) use orotidine as a slow substrate in the pyrophosphorolysis reaction. With orotidine, intrinsic kinetic isotope effects (KIEs) can be measured for pyrophosphor... |
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The allopurinol load test lacks specificity for primary urea cycle defects but may indicate unrecognized mitochondrial disease.
J. Inherit. Metab. Dis. 22(2) , 174-84, (1999) Thirty-three children ranging from 2 weeks to 12 years of age were selected for allopurinol loading, 16 on the basis of an increased urinary ourotate excretion detected by routine organic acid analysis (group A), and 17 for clinical reasons suggesting a urea ... |
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Orotidine accumulation in human erythrocytes during allopurinol therapy: association with high urinary oxypurinol-7-riboside concentrations in renal failure and in the Lesch-Nyhan syndrome.
Clin. Sci. 80(3) , 191-7, (1991) 1. A compound identified as orotidine has been found in the erythrocytes of all subjects on allopurinol. 2. The erythrocyte orotidine concentrations were much higher in patients with renal failure or with the Lesch-Nyhan syndrome. 3. In addition, increased am... |
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The effective molarity of the substrate phosphoryl group in the transition state for yeast OMP decarboxylase.
Bioorg. Chem. 33(1) , 45-52, (2005) The second order rate constant (k(cat)/K(m)) for decarboxylation of orotidine by yeast OMP decarboxylase (ODCase), measured by trapping (14)CO(2) released during the reaction, is 2 x 10(-4)M(-1)s(-1). This very low activity may be compared with a value of 3 x... |
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Influence of dose and age on the response of the allopurinol test for ornithine carbamoyltransferase deficiency in control infants.
J. Inherit. Metab. Dis. 23(7) , 662-8, (2000) Measurement of urinary orotidine and orotic acid after an oral allopurinol challenge is an important diagnostic test for ornithine carbamoyltransferase deficiency that is sometimes used in infants (< 1 year of age), although there is little information on nor... |
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The allopurinol loading test in detecting obligate heterozygotes for OCT deficiency.
J. Inherit. Metab. Dis. 17(1) , 133-4, (1994)
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Effect of allopurinol and benzbromarone on the concentration of uridine in plasma.
Metab. Clin. Exp. 46(12) , 1473-6, (1997) To investigate whether allopurinol and benzbromarone affect the concentration of uridine in plasma, allopurinol or benzbromarone were administered to patients with gout for 3 to 6 months. Allopurinol decreased the concentrations of uridine and uric acid in pl... |
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Antagonistic effect of nucleic acid precursors on the anticoccidial activity of 6-azauracil.
J. Vet. Med. Sci. 58(2) , 121-7, (1996) The antagonistic phenomena to anticoccidial activities of 6-azauracil (AzU) induced by certain nucleic acid precursors were examined in battery experiments. Each nucleic acid precursor, orotate, orotidine, uracil, uridine, adenine and adenosine was mixed in f... |
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Investigation for the characteristic anticoccidial activity of diclazuril in battery trials.
J. Vet. Med. Sci. 58(2) , 129-33, (1996) To clarify the character of the anticoccidial activity of diclazuril a series of battery trials was conducted. Diclazuril showed excellent anticoccidial activity in the infection of chickens with Eimeria tenella, E. necatrix or E. acervulina at the feeding le... |
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Synthesis of carbocyclic orotidine analogs as potential orotidine decarboxylase inhibitors.
Nucleosides Nucleotides Nucleic Acids 20(12) , 1915-25, (2001) An asymmetric synthesis of carbocyclic orotidine 15 and its monophosphate 16 were accomplished via the key intermediate cyclopentanone 4, which was prepared from D-gamma-ribonolactone in steps. None of synthesized the compounds inhibited orotidine 5'-monophos... |