[Des-Tyr1] g-Endorphin
![[Des-Tyr1] g-Endorphin Structure](https://image.chemsrc.com/caspic/483/67810-56-4.png)
[Des-Tyr1] g-Endorphin structure
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Common Name | [Des-Tyr1] g-Endorphin | ||
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| CAS Number | 67810-56-4 | Molecular Weight | 1695.93000 | |
| Density | 1.319 g/cm3 | Boiling Point | 2014.8ºC at 760 mmHg | |
| Molecular Formula | C74H122N18O25S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 1172.3ºC | |
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Interaction between des-Tyr1-gamma-endorphin and HLA class I molecules: serological detection of an HLA-A2 subtype.
Immunogenetics 22(4) , 309-14, (1985) Preincubation of lymphocytes with des-Tyr1-gamma-endorphin (DT gamma E) inhibits the reaction between some HLA alloantisera and their corresponding antigens. One HLA-A2-specific antiserum was found which could detect a subtype of the HLA-A2 antigen on DT gamm... |
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Des-tyrosine-gamma-endorphin effects on morphine analgesia in mice.
Gen. Pharmacol. 24(1) , 83-8, (1993) 1. The effects that were induced by a beta-lipotropin fragment des-tyrosine-gamma-endorphin (DT gamma E) devoid of opiate activity that was administered intraperitoneally or intracerebroventricularly to mice under morphine analgesia were investigated. The int... |
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Short-lived effect of (Des-Tyr)-gamma-endorphin in schizophrenia.
Psychiatry Res. 10(4) , 243-52, (1983) Des-tyrosine-gamma-endorphin (DT gamma E) has been reported to alleviate symptoms of schizophrenia. Attempting to replicate those reports, we administered 1 mg of DT gamma E, i.m., for 8 consecutive days to nine patients meeting the DSM-III criteria for schiz... |
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Subchronic treatment with fragments of beta-endorphin prevents electroencephalographic seizures and behavioral alterations induced by centrally administered beta-endorphin in the rabbit.
J. Pharmacol. Exp. Ther. 268(2) , 1040-50, (1994) The effects of some beta-endorphin fragments with neuroleptic-like properties, i.e., tau-endorphin, des-tyr1-tau-endorphin (DT tau E), desenkephalin-tau-endorphin (DE tau E), in comparison with the dopaminergic antagonist haloperidol,- were studied on the EEG... |
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Criteria for evaluating improvement in schizophrenia in psychopharmacological research (with special reference to gamma endorphin fragments).
Br. J. Psychiatry 153 , 354-8, (1988) A review of treatment trials with DT gamma E revealed widely discrepant results. Relevant variables were the variety of measures employed for monitoring psychotic symptoms, and the different criteria used to judge the degree of improvement. The authors sugges... |
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A treatment trial with an analog of thyrotropin-releasing hormone (DN-1417) and des-tyrosine-gamma-endorphin in schizophrenia.
Int. Clin. Psychopharmacol. 1(4) , 303-13, (1986) Clinical prospects of an analog of thyrotropin-releasing hormone (DN-1417) and des-tyrosine-gamma-endorphin (DT gamma E) in schizophrenia were examined by using the Brief Psychiatric Rating Scale (BPRS) and the electroencephalogram (EEG). Twelve inpatients wi... |
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Beta-endorphin fragments (DT gamma E and DE gamma E) reduce opiate withdrawal in guinea pig ileum.
Prog. Neuropsychopharmacol. Biol. Psychiatry 26(2) , 313-9, (2002) The effect exerted by two beta-endorphin fragments (DTgammaE and DEgammaE) was investigated on the acute opioid dependence induced by mu, kappa and delta receptor agonists in vitro. After a 4-min in vitro exposure to morphine (less selective mu agonist), DAGO... |
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Guinea-pigs treated with beta-endorphin fragments DTgammaE and DEgammaE exhibit reduced morphine inhibition of electrically-induced contractions.
Prog. Neuropsychopharmacol. Biol. Psychiatry 24(1) , 51-9, (2000) The effect exerted by two gamma-endorphin derivatives (DTgammaE and DEgammaE) was investigated on morphine-induced inhibition on the electrically contractions of guinea pig ileum in vitro. Morphine (1x10(-8)-5x10(-8)-1x10(-7) M) dose dependently and significa... |
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Effect of des-tyrosine-gamma-endorphin on neocortical spike-and-wave spindling in DBA/2J mice.
Eur. J. Pharmacol. 261(1-2) , 209-12, (1994) The effect of a beta-endorphin cleavage product devoid of opioid effects, des-tyrosine-gamma-endorphin (DT gamma E) on the neocortical spike-and-wave spindling episodes in the electrocorticogram (ECoG) of DBA/2J mice was studied. DT gamma E (0.01-1.0 mg/kg, i... |
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Porphyrin synthesis in primary nervous tissue cultures from 10(-3) M delta-aminolaevulinic acid in the presence of melatonin and neuropeptides.
Neurochem. Res. 11(5) , 607-15, (1986) Of the primary neuronal tissue cultures (glia cell, neuronal cells, mixed and retina cultures), the neuronal cells of (cells + medium) display the highest total porphyrin production from 10(-3) M delta-aminolaevulinic acid (ALA). In the presence of 10(-3)-10(... |