[Glu2]-TRH
![[Glu2]-TRH Structure](https://image.chemsrc.com/caspic/090/85541-78-2.png)
[Glu2]-TRH structure
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Common Name | [Glu2]-TRH | ||
|---|---|---|---|---|
| CAS Number | 85541-78-2 | Molecular Weight | 354.35800 | |
| Density | 1.416g/cm3 | Boiling Point | 899.9ºC at 760 mmHg | |
| Molecular Formula | C15H22N4O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 498ºC | |
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Fertilization promoting peptide--a possible regulator of sperm function in vivo.
Vitam. Horm. 63 , 1-28, (2001) Fertilization promoting peptide (FPP), a tripeptide related to thyrotrophin releasing hormone (TRH), is found in seminal plasma. Recent evidence obtained in vitro suggests that FPP may play an important role in regulating sperm fertility in vivo. Specifically... |
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Fertilization promoting peptide and adenosine, acting as first messengers, regulate cAMP production and consequent protein tyrosine phosphorylation in a capacitation-dependent manner.
Mol. Reprod. Dev. 57(4) , 384-92, (2000) Fertilization promoting peptide (FPP) and adenosine have been shown to act as first messengers, regulating availability of the second messenger cAMP by initially stimulating cAMP production in uncapacitated spermatozoa and then inhibiting it in capacitated ce... |
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In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH(2) (EEP).
Peptides 22(12) , 2091-7, (2001) EEP is a tripeptide structurally similar to thyrotropin releasing hormone (TRH) and, like TRH, it is found in the mammalian brain. TRH has been found to increase in brain regions after seizures and to be neuroprotective. EEP has also been shown to increase in... |
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Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide.
Mol. Hum. Reprod. 8(1) , 24-31, (2002) A human testis-specific gene was isolated by subtractive hybridization between the cDNA pools of adult and fetal testes, followed by rapid amplification of cDNA ends (RACE). This gene sequence is highly homologous to a large portion of the mouse Tcp11 gene wh... |
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Substrate specificity of glutaminyl cyclases from plants and animals.
Biol. Chem. 384(12) , 1583-92, (2003) Glutaminyl cyclases (QC) catalyze the intramolecular cyclization of N-terminal glutamine residues of peptides and proteins. For a comparison of the substrate specificity of human and papaya QC enzymes, a novel continuous assay was established by adapting an e... |
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Role of TRH receptors as possible mediators of analeptic actions of TRH-like peptides.
Brain Res. 935(1-2) , 59-64, (2002) A large family of TRH-like peptides in the limbic region of rat brain including pGlu-Glu-Pro-NH(2) (EEP), pGlu-Val-Pro-NH(2) (Val(2)-TRH), Leu(2)-TRH, Phe(2)-TRH and Tyr(2)-TRH has recently been discovered. TRH (pGlu-His-Pro-NH(2)) has antidepressant, neuropr... |
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Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2.
Bioorg. Med. Chem. Lett. 13(6) , 1011-4, (2003) Potential prodrugs for the TRH-like tripeptide pGlu-Glu-Pro-NH(2) were synthesized either by esterifying the Glu side-chain of the parent peptide in solution with alcohols in the presence of resin-bound dicyclohexylcarbodiimide or by solid-phase peptide chemi... |
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Characterization of a circulating N-extended form of the thyrotropin-releasing hormone-like peptide pGlu-Glu-Pro amide in human plasma.
J. Clin. Endocrinol. Metab. 88(12) , 6002-7, (2003) The TRH-like peptides pGlu-Glu-Pro amide, pGlu-Phe-Pro amide, and pGlu-Gln-Pro amide were isolated and identified some years ago, and these peptides have been proven to be present in many tissues and fluids. The presence of TRH-like immunoreactivity distinct ... |
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Electroconvulsive seizures modulate levels of thyrotropin releasing hormone and related peptides in rat hypothalamus, cingulate and lateral cerebellum.
Brain Res. 884(1--2) , 174-83, (2000) We have studied the neuroanatomic extent of electroconvulsive (ECS)-responsive prepro-TRH and TRH-related gene expression and its possible interaction with forced swimming. Young adult male Wistar rats were treated in a 2x2 Latin square protocol of swimming, ... |
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Effect of a fertilization-promoting peptide on the fertilizing ability and glycosidase activity in vitro of frozen-thawed spermatozoa in the pig.
Anim. Reprod. Sci. 72(1-2) , 83-94, (2002) This study has evaluated the effect of fertilization-promoting peptide (FPP) on the fertilizing ability and glycosidase activity in vitro of frozen-thawed boar spermatozoa. Use of chlortetracycline (CTC) fluorescence analysis, as well as various glycosidase a... |