N4-Acetylsulfamethoxazole
N4-Acetylsulfamethoxazole structure
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Common Name | N4-Acetylsulfamethoxazole | ||
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| CAS Number | 21312-10-7 | Molecular Weight | 295.31400 | |
| Density | 1.448g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C12H13N3O4S | Melting Point | 222ºC dec. | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Excretion rates of sulfamethoxazole and N4-acetyl-sulfamethoxazole by fresh water turtles Pseudemys scripta elegans.
Vet. Q. 6(3) , 169-73, (1984) Sulfamethoxazole and N4-acetylsulfamethoxazole are excreted by fresh water turtles Pseudemys scripta elegans in a biphasic mode, characterized half-lives of 5 and 100 min. Acetylation and deacetylation reactions cannot be detected below a dose of 50 mg/kg. Th... |
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Multiple-dose pharmacokinetics of 12 milligrams of trimethoprim and 60 milligrams of sulfamethoxazole per kilogram of body weight per day in healthy volunteers.
Antimicrob. Agents Chemother. 37(3) , 448-52, (1993) The disposition of 12 mg of trimethoprim and 60 mg of sulfamethoxazole per kg of body weight in six healthy male volunteers is described. The daily dose was evenly divided and administered orally every 6 h for 13 consecutive doses. Individual drug components ... |
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Sampling the lipogenic hepatic acetyl-CoA pool in vivo in the rat. Comparison of xenobiotic probe to values predicted from isotopomeric distribution in circulating lipids and measurement of lipogenesis and acetyl-CoA dilution.
J. Biol. Chem. 266(17) , 10912-9, (1991) The acetylation of xenobiotics may provide a means for sampling hepatic cytosolic acetyl-CoA in vivo for isotopic studies of lipogenesis. Here, we test the accuracy of acetylated-sulfamethoxazole (SMX) in representing the true precursor pool for hepatic lipog... |
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Pharmacokinetics of the trimethoprim-sulphamethoxazole combination in the elderly.
Br. J. Clin. Pharmacol. 20(6) , 575-81, (1985) The pharmacokinetics of a co-trimoxazole preparation (Bactrim Forte) containing trimethoprim (TMP) 160 mg and sulphamethoxazole (SMZ) 800 mg were determined in six young adults (29.3 +/- 4.4 s.d. years) and six elderly people (78.6 +/- 6.6 s.d. years). Follow... |
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Rapid simultaneous determination of trimethoprim, sulphamethoxazole and acetylsulphamethoxazole in human plasma and urine by high-performance liquid chromatography.
J. Pharm. Biomed. Anal. 9(6) , 507-10, (1991)
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Acetylation, deacetylation and hydroxylation of sulphamethoxazole and N4-acetylsulphamethoxazole in the snail Cepaea hortensis.
Vet. Q. 9(4) , 378-81, (1987) The snail Cepaea hortensis is able to acetylate and hydroxylate sulphamethoxazole in a similar way to man. About one percent deacetylation, but no hydroxylation of N4-acetysulphamethoxazole takes place. The relative rates of the metabolic pathways for hydroxy... |
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Comparison of the conventional methods and high-performance liquid chromatography for the determination of trimethoprim, sulfamethoxazole and its metabolite in serum.
Chemotherapy 28(4) , 247-52, (1982) A modified high-performance liquid chromatographic (HPLC) method for sensitive and rapid determination of trimethoprim, sulfamethoxazole and its metabolite N4-acetylsulfamethoxazole has been compared with the bioassay for trimethoprim and a colorimetric proce... |
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Comparison of the pharmacokinetics of sulfamethoxazole in male chinese volunteers at low altitude and acute exposure to high altitude versus subjects living chronically at high altitude: an open-label, controlled, prospective study.
Clin. Ther. 31(11) , 2744-54, (2009) Sulfamethoxazole is an antibacterial sulfonamide used primarily for the treatment of a wide variety of bacterial infections in combination with trimethoprim. Despite being used as prophylactic treatment for respiratory infections associated with high altitude... |
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Variability of serum concentrations of trimethoprim and sulfamethoxazole during high dose therapy.
Infection 21(4) , 206-9, (1993) Serum kinetics of trimethoprim and sulfamethoxazole were studied in 23 patients during oral and i.v. treatment of Pneumocystis carinii pneumonia. Daily doses of 15-22 mg/kg trimethoprim and 75-110 mg/kg sulfamethoxazole were given every 6 h. Despite administr... |
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Assay of the acetyl-CoA probe acetyl-sulfamethoxazole and of sulfamethoxazole by gas chromatography-mass spectrometry.
Anal. Biochem. 212(2) , 481-6, (1993) We present gas chromatographic-mass spectrometric assays for (i) the concentration of sulfamethoxazole and (ii) the concentration and molar percentage enrichment of acetyl-sulfamethoxazole in biological fluids. The compounds are extracted with ethyl acetate, ... |