Isoprenaline
Isoprenaline structure
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Common Name | Isoprenaline | ||
|---|---|---|---|---|
| CAS Number | 6700-39-6 | Molecular Weight | 211.258 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 417.5±40.0 °C at 760 mmHg | |
| Molecular Formula | C22H40N2O12S | Melting Point | 130°C | |
| MSDS | N/A | Flash Point | 179.7±17.9 °C | |
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Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts.
Circ. Res. 114(6) , 993-1003, (2014) β-Adrenoceptor activation contributes to sudden death risk in heart failure. Chronic β-adrenergic stimulation, as occurs in patients with heart failure, causes potentially arrhythmogenic reductions in slow delayed-rectifier K(+) current (IKs).To assess the mo... |
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Protein kinetic signatures of the remodeling heart following isoproterenol stimulation.
J. Clin. Invest. 124(4) , 1734-44, (2014) Protein temporal dynamics play a critical role in time-dimensional pathophysiological processes, including the gradual cardiac remodeling that occurs in early-stage heart failure. Methods for quantitative assessments of protein kinetics are lacking, and despi... |
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Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes.
Toxicol. Lett. 226(3) , 257-63, (2014) Cardiac hypertrophy is an independent risk factor for cardiovascular disease and its subsequent progression to heart failure represents a major cause of morbidity and mortality in the world. CGA is an important component of Chinese herbal medicine, acting as ... |
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Accentuation of ursolic acid on muscarinic receptor-induced ANP secretion in beating rabbit atria.
Life Sci. 94(2) , 145-50, (2014) Ursolic acid has recently been reported to increase both atrial natriuretic peptide (ANP) secretion and mechanical dynamics in rabbit atria.The present study was designed to clarify the regulatory effects of ursolic acid on the β-adrenergic or muscarinic rece... |
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DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2.
Toxicology 323 , 42-50, (2014) Cardiac fibrosis contributes to the pathogenesis of atrial fibrillation (AF). The molecular mechanisms underlying the cardiac fibrosis remain unclear. However, Ras association domain family 1 isoform A (RASSF1A) is a regulatory tumor suppressor, which is impo... |
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An alpha-adrenergic agonist protects hearts by inducing Akt1-mediated autophagy.
Biochem. Biophys. Res. Commun. 456(1) , 250-6, (2015) Alpha-adrenergic agonists is known to be protective in cardiac myocytes from apoptosis induced by beta-adrenergic stimulation. Although there has been a recent focus on the role of cardiac autophagy in heart failure, its role in heart failure with adrenergic ... |
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Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation.
Circ. Res. 114(9) , 1410-21, (2014) Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia.To measure intra-SR free [Ca(2+)] ([Ca(2+)]SR) changes in intact hearts during alternans and v... |
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Monomorphic sustained ventricular tachycardia late after arterial switch for d-transposition of the great arteries: ablation in the sinus of valsalva.
Can. J. Cardiol. 29(12) , 1741.e13-5, (2013) We describe the case of a young boy with d-transposition of the great arteries (TGA) that was surgically corrected with an arterial switch operation, who presented with sustained ventricular tachycardia (VT) that was successfully ablated at the embryologic pu... |
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Attenuated aortic vasodilation and sympathetic prejunctional facilitation in epinephrine-deficient mice: selective impairment of β2-adrenoceptor responses.
J. Pharmacol. Exp. Ther. 351(2) , 243-9, (2014) It has been suggested that there is a link between epinephrine synthesis and the development of β2-adrenoceptor-mediated effects, but it remains to be determined whether this development is triggered by epinephrine. The aim of this study was to characterize β... |
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Metformin protects the myocardium against isoproterenol-induced injury in rats through alleviating endoplasmic reticulum stress.
Pharmazie 69(1) , 64-9, (2014) Clinical studies have suggested that metformin, a widely used antidiabetic agent, exerts a direct cardioprotective effect on cardiovascular disease in addition to its blood glucose-lowering activity. This study was designed to identify the role of metformin i... |