Biapenem
Biapenem structure
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Common Name | Biapenem | ||
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| CAS Number | 120410-24-4 | Molecular Weight | 350.393 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H18N4O4S | Melting Point | 265-271°C (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2010: General view of the pathogens' antibacterial susceptibility.
J. Infect. Chemother. 21 , 410-20, (2015) The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from patients in Japan, was conducted by Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases and Japanese Society for Clinical Microbiolo... |
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Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii.
Antimicrob. Agents Chemother. 59 , 2286-98, (2015) Acinetobacter baumannii is among the most dangerous pathogens and emergence of resistance is highly problematic. Our objective was to identify and rationally optimize β-lactam-plus-aminoglycoside combinations via novel mechanism-based modeling that synergisti... |
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Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the post-hydrolysis reactions.
PLoS ONE 7(1) , e30079, (2012) The first line of defense by bacteria against β-lactam antibiotics is the expression of β-lactamases, which cleave the amide bond of the β-lactam ring. In the reaction of biapenem inactivation by B2 metallo β-lactamases (MβLs), after the β-lactam ring is open... |
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The stability of biapenem and structural identification of impurities in aqueous solution.
J. Pharm. Biomed. Anal. 49(4) , 937-44, (2009) The stability of biapenem in aqueous solution was investigated. Forced degradation of biapenem was carried out under different concentrations, pH values and temperatures. The degradation products were determined by reverse-phase HPLC and identified by LC-MS/M... |
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Metallo-beta-lactamase inhibitory activity of phthalic acid derivatives.
Bioorg. Med. Chem. Lett. 19 , 5162-5, (2009) 4-Butyl-3-methylphthalic acid was recognized as a metallo-beta-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted... |
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Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the hydrolysis reaction.
PLoS ONE 8(1) , e55136, (2013) A general mechanism has been proposed for metallo β-lactamases (MβLs), in which deprotonation of a water molecule near the Zn ion(s) results in the formation of a hydroxide ion that attacks the carbonyl oxygen of the β-lactam ring. However, because of the abs... |
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Evaluation of the efficacy and safety of biapenem against pneumonia in the elderly and a study on its pharmacokinetics.
J. Infect. Chemother. 19(1) , 98-102, (2013) Although biapenem is used in the treatment of pneumonia, the clinical data on elderly patients are yet insufficient. Therefore, the purpose of this study was evaluating the efficacy and safety of biapenem against pneumonia in the elderly and its pharmacokinet... |
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Pharmacokinetic-pharmacodynamic target attainment analysis of biapenem in adult patients: a dosing strategy.
Chemotherapy 54(5) , 386-94, (2008) A pharmacokinetic-pharmacodynamic (PK-PD) target attainment analysis to build a dosing strategy for biapenem in adult patients has not been conducted.A total of 321 plasma concentration samples from 68 adult patients (1-6 samples per patient) were assayed bio... |
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A multicenter, randomized controlled clinical study on biapenem and imipenem/cilastatin injection in the treatment of respiratory and urinary tract infections.
Chemotherapy 56(4) , 285-90, (2010) Biapenem is an injectable carbapenem antibiotic. A clinical study was designed to evaluate its efficacy and safety in the treatment of respiratory and urinary infections compared to imipenem/cilastatin.A total of 216 patients with respiratory or urinary tract... |
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The use of UV, FT-IR and Raman spectra for the identification of the newest penem analogs: solutions based on mathematic procedure and the density functional theory.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 103 , 435-41, (2013) The application of ultraviolet, FT-IR and Raman spectra was proposed for identification studies of the newest penem analogs (doripenem, biapenem and faropenem). An identification of the newest penem analogs based on their separation from related substances wa... |