Ac-Gly-OH
Ac-Gly-OH structure
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Common Name | Ac-Gly-OH | ||
|---|---|---|---|---|
| CAS Number | 543-24-8 | Molecular Weight | 117.103 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 405.1±28.0 °C at 760 mmHg | |
| Molecular Formula | C4H7NO3 | Melting Point | 207-209 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 198.8±24.0 °C | |
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HMDB: a knowledgebase for the human metabolome.
Nucleic Acids Res. 37(Database issue) , D603-10, (2009) The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Si... |
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The human serum metabolome.
PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite ref... |
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Coformer screening using thermal analysis based on binary phase diagrams.
Pharm. Res. 31(8) , 1946-57, (2014) The advent of cocrystals has demonstrated a growing need for efficient and comprehensive coformer screening in search of better development forms, including salt forms. Here, we investigated a coformer screening system for salts and cocrystals based on binary... |
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Molecular docking and ligand specificity in fragment-based inhibitor discovery.
Nat. Chem. Biol. 5 , 358-64, (2009) Fragment screens have successfully identified new scaffolds in drug discovery, often with relatively high hit rates (5%) using small screening libraries (1,000-10,000 compounds). This raises two questions: would other noteworthy chemotypes be found were one t... |
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Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).
Bioorg. Med. Chem. 16 , 10061-74, (2008) Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human disease and ... |
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Extraction and GC/MS analysis of the human blood plasma metabolome.
Anal. Chem. 77(24) , 8086-94, (2005) Analysis of the entire set of low molecular weight compounds (LMC), the metabolome, could provide deeper insights into mechanisms of disease and novel markers for diagnosis. In the investigation, we developed an extraction and derivatization protocol, using e... |
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Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry.
Anal. Biochem. 308 , 285-293, (2002) The hydrolysis of N-acetyl-L-methionine, N-acetylglycine, N-acetyl-L-phenylalanine, and N-acetyl-L-alanine at 298.35K by porcine kidney acylase I (EC 3.5.1.14) was monitored by the heat released upon mixing of the substrate and enzyme in a differential stoppe... |
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Temperature dependence of the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry.
Anal. Biochem. 321(1) , 1-7, (2003) The rates of the hydrolysis of N-acetylglycine, N-acetyl-L-methionine, and N-acetyl-L-phenylalanine by porcine acylase I in 0.1M phosphate buffer, which is inhibited by acetate product formation, were monitored calorimetrically at temperatures between 15.2 an... |
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Aminoacylase I deficiency: a novel inborn error of metabolism.
Biochem. Biophys. Res. Commun. 338(3) , 1322-6, (2005) This is the first report of a patient with aminoacylase I deficiency. High amounts of N-acetylated amino acids were detected by gas chromatography-mass spectrometry in the urine, including the derivatives of serine, glutamic acid, alanine, methionine, glycine... |
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Substrate specificity of an acylaminopeptidase that catalyzes the cleavage of the blocked amino termini of peptides.
Biochim. Biophys. Acta 953(3) , 357-60, (1988) An acylaminopeptidase purified from human red cells cleaves acetylated dipeptides in the decreasing order of acetyl-Ala, acetyl-Met, acetyl-Ser, acetyl-Gly and acetyl-Val. In addition, it was also found that the nature of the second amino-acid residue influen... |