Homocysteic acid
Homocysteic acid structure
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Common Name | Homocysteic acid | ||
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| CAS Number | 504-33-6 | Molecular Weight | 183.183 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C4H9NO5S | Melting Point | 273 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
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15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ.
J. Neurochem. 124(4) , 536-47, (2013) Astrocytes are critical for the antioxidant support of neurons. Recently, we demonstrated that low level hydrogen peroxide (H(2) O(2) ) facilitates astrocyte-dependent neuroprotection independent of the antioxidant transcription factor Nrf2, leaving the ident... |
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Prebiotic synthesis of methionine and other sulfur-containing organic compounds on the primitive Earth: a contemporary reassessment based on an unpublished 1958 Stanley Miller experiment.
Orig. Life Evol. Biosph. 41(3) , 201-12, (2011) Original extracts from an unpublished 1958 experiment conducted by the late Stanley L. Miller were recently found and analyzed using modern state-of-the-art analytical methods. The extracts were produced by the action of an electric discharge on a mixture of ... |
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Nucleus raphe pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during electroacupuncture.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 299(5) , R1369-76, (2010) We have shown that electroacupuncture (EA) inhibits sympathoexcitatory rostral ventrolateral medulla (rVLM) neurons and reflex responses following activation of a long-loop pathway in the arcuate nucleus and ventrolateral periaqueductal gray (vlPAG). Addition... |
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Activation of N-methyl D-aspartate (NMDA) receptors has no influence on rheological properties of erythrocytes.
Clin. Hemorheol. Microcirc. 49(1-4) , 307-13, (2011) Red blood cells (RBCs) express N-methyl D-aspartate (NMDA) receptors on their surface. We tested if NMDA receptor activation or inhibition had an influence on RBC deformability and aggregability.Heparinized blood was drawn from healthy volunteers and centrifu... |
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Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter.
Behav. Brain Res. 213(2) , 195-200, (2010) Electrical or chemical stimulation of the dorsal periaqueductal gray matter (DPAG) evokes escape, a defensive behavior that has been related to panic attacks. Injection of 5-HT(1A) or 5-HT(2A) receptor agonists into this midbrain area inhibits this response. ... |
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Conversion of methionine into homocysteic acid in heavily oxidized proteomics samples.
Rapid Commun. Mass Spectrom. 24(6) , 768-72, (2010) Analysis of protein oxidation is necessary in numerous areas of biochemistry, including hydroxyl radical surface mapping, oxidative stress assays, and pharmaceutical stability testing. Mass spectrometry is one of the tools most often used to identify protein ... |
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Sympathetic premotor neurones project to and are influenced by neurones in the contralateral rostral ventrolateral medulla of the rat in vivo.
Brain Res. 1439 , 34-43, (2012) The tonic activity of bulbospinal neurones in the rostral ventrolateral medulla (RVLM) is thought to underlie basal sympathetic nerve activity. A key research objective is to delineate the mechanisms that contribute to the firing of these neurones. In the cur... |
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Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist.
Behav. Brain Res. 225(2) , 491-7, (2011) For patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma, intrathecal (IT) methotrexate (MTX) significantly reduces the risk of relapse within the central nervous system, but is associated with neurotoxic sequelae. We established a rat model of ... |
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Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 301(6) , R1765-72, (2011) Sympathoexcitation and increased blood pressure evoked by central networks integrating defensive behavior are fundamental to the acute stress response. A balance between excitatory glutamatergic and inhibitory GABAergic neurotransmission in the dorsal periaqu... |
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Urinary homocysteic acid levels correlate with mini-mental state examination scores in Alzheimer's disease patients.
J. Alzheimers Dis. 31(1) , 59-64, (2012) Homocysteic acid (HA) has been suggested as a pathogen in a mouse model of Alzheimer's disease (AD), 3xTg-AD. However, it is not established whether HA is involved in humans. We investigated the relationship between urinary HA levels and Mini-Mental State Exa... |