Lewis-a trisaccharide
Lewis-a trisaccharide structure
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Common Name | Lewis-a trisaccharide | ||
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| CAS Number | 56570-03-7 | Molecular Weight | 529.49000 | |
| Density | 1.6g/cm3 | Boiling Point | 977.2ºC at 760mmHg | |
| Molecular Formula | C20H35NO15 | Melting Point | 160-162ºC | |
| MSDS | USA | Flash Point | 544.8ºC | |
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N-glycans harboring the Lewis a epitope are expressed at the surface of plant cells.
Plant J. 12(6) , 1411-7, (1997) In plants, N-linked glycans are processed in the Golgi apparatus to complex-type N-glycans of limited size containing a beta(1,2)-xylose and/or an alpha(1,3)-fucose residue. Larger mono- and bi-antennary N-linked complex glycans have not often been described.... |
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Studies on the three-dimensional behaviour of the selectin ligands Lewis(a) and sulphated Lewis(a) using NMR spectroscopy and molecular dynamics simulations.
Glycobiology 4(1) , 49-57, (1994) Sulphated blood group Lewis(a)/Lewis(x) (Le(a)/Le(x)) type sequences, with sulphate at the 3-position of galactose, have emerged as potent ligands for the endothelial adhesion molecule E-selectin and the leukocyte adhesion molecule L-selectin. As a first step... |
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CA-S27: a novel Lewis a associated carbohydrate epitope is diagnostic and prognostic for cholangiocarcinoma.
Cancer Sci. 104 , 1278-1284, (2013) Early and specific diagnosis is critical for treatment of cholangiocarcinoma (CCA). In this study, a carbohydrate antigen-S27 (CA-S27) monoclonal antibody (mAb) was established using pooled CCA tissue-extract as immunogen. The epitope recognized by CA-S27-mAb... |
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Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells.
J. Immunol. 170 , 1635-1639, (2003) Dendritic cells (DC) are instrumental in handling pathogens for processing and presentation to T cells, thus eliciting an appropriate immune response. C-type lectins expressed by DC function as pathogen-recognition receptors; yet their specificity for carbohy... |
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Chemical synthesis of 2-acetamido-2-deoxy-4-O-(a-L-fucopyranosyl)-3-O-(ß-D-galactopyranosyl)-D-glucose. Lewis a blood-group antigenic determinant. Lemieux, R.U. and Driguez, H.
J. Am. Chem. Soc. 97 , 4063-4069, (1975)
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