18-Hydroxycorticosterone
18-Hydroxycorticosterone structure
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Common Name | 18-Hydroxycorticosterone | ||
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| CAS Number | 561-65-9 | Molecular Weight | 362.46000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H30O5 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 2 °C - closed cup (lit.) | |
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Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).
J. Med. Chem. 53 , 1712-25, (2010) Reducing aldosterone action is beneficial in various major diseases such as heart failure. Currently, this is achieved with mineralocorticoid receptor antagonists, however, aldosterone synthase (CYP11B2) inhibitors may offer a promising alternative. In this s... |
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["High pouch output" syndrome. Role of mineralocorticoid diagnosis after restorative proctocolectomy].
Chirurg. 72(12) , 1446-52, (2001) The two-phase restorative proctocolectomy is the treatment of choice for surgical therapy of the familial adenomatous polyposis (FAP) and also for the ulcerative colitis (UC). Besides the well-known complications the entire removal of the colorectum leads to ... |
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Dose-dependence of the effects of corticosterone and the non-glucocorticoid, 18-hydroxycorticosterone, on the brush-border Na+/K+ exchanger.
Endocr. Res. 24(3-4) , 601-5, (1998) Up to now, only glucocorticoids were thought to act on the renal proximal Na+/H+ exchanger. Using fluorimetric techniques we studied the kinetics of Na+/H+ exchange in brush border vesicles from ADX rats treated with increasing doses of corticosterone (B) and... |
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[18-Hydroxycorticosterone, 18-hydroxydesoxycorticosterone. Why, when, how to determine plasma levels in some adrenal pathologies].
Ann. Endocrinol. (Paris.) 51(1) , 1-15, (1990) The authors review some current ideas concerning the role of 18-hydroxylated corticosteroids as mineralocorticoids themselves and as possible precursors of the principal mineralocorticoid, aldosterone. In particular, the physiological and pharmacological agen... |
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Primary aldosteronism and its variants.
Cardiovasc. Res. 37(1) , 8-13, (1998)
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Effect of chronic adrenocorticotropin stimulation on the excretion of 18-hydroxycortisol and 18-oxocortisol.
J. Clin. Endocrinol. Metab. 67(2) , 322-6, (1988) The human adrenal gland can metabolize cortisol to yield steroids oxygenated at the 18 position in a series of reactions similar to those by which corticosterone is converted to 18-hydroxycorticosterone and aldosterone and perhaps catalyzed by the same enzyme... |
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Liver lesion detection and characterization in patients with colorectal cancer: a comparison of low radiation dose non-enhanced PET/CT, contrast-enhanced PET/CT, and liver MRI.
J. Comput. Assist. Tomogr. 32(5) , 738-44, (2008) To compare low-radiation dose non-enhanced fluorine 18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET)/computed tomography (CT) (NE-PET/CT), contrast-enhanced fluorine 18 fluorodeoxyglucose PET/CT (CE-PET/CT), and gadolinium-enhanced liver ma... |
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Determination of corticosterone and 17-hydroxycorticosterone in plasma and urine samples by sweeping techniques using micellar electrokinetic chromatography.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 801(2) , 347-53, (2004) The analysis of corticosterone in mouse blood serum (metabolic-stress experiment) and 17-hydroxycorticosterone in human urine (exercise-stress experiment) samples by means of capillary electrophoresis/UV absorbance in conjunction with online sample concentrat... |
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Measurement of 18-hydroxycorticosterone during adrenal vein sampling for primary aldosteronism.
J. Clin. Endocrinol. Metab. 92(7) , 2648-51, (2007) In primary aldosteronism, elevated serum 18-hydroxycorticosterone (18OHB) suggests aldosterone-producing adenoma (APA) rather than bilateral, idiopathic hyperaldosteronism (IHA), but little is known about the relative production of 18OHB and aldosterone (A) i... |
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Mutations in aldosterone synthase gene of Milan hypertensive rats: phenotypic consequences.
Am. J. Physiol. Endocrinol. Metab. 282(3) , E608-17, (2002) Using in vitro and in vivo methods, we have demonstrated increased sensitivity of adrenocortical steroidogenesis to ACTH in Milan hypertensive (MHS) compared with normotensive (MNS) rats and have investigated whether this is caused by mutations of steroidogen... |